Regulation of inflammation by SOCS1 and SOCS3 in the syngeneic bone marrow transplantation
Project/Area Number |
15K19547
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Hematology
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Research Institution | Niigata University |
Principal Investigator |
Ushiki Takashi 新潟大学, 医歯学総合病院, 講師 (80579152)
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Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | SOCS1 / SOCS3 / 慢性炎症 / 遺伝子間相互作用 / 骨髄移植 / SOCS / GVHD |
Outline of Final Research Achievements |
Combined hematopoietic loss of SOCS1 and SOCS3 causes rapid inflammatory disease in the syngeneic bone marrow transplantation. Loss of SOCS1 increases the number of CD8+CD44high cells. The expression of homing markers on these T cells may facilitate migration to organs and tissues, and the propensity for production of pro-inflammatory cytokines and chemokines, such as RANTES, MIP1a, GM-CSF and IL-3 for recruiting myeloid cells, as well as development of high circulating G-CSF concentrations, can account for the pathological infiltration of neutrophils, monocytes, eosinophils and lymphocytes at the numerous sites of inflammation in SOCS1KO mice. Our data extend the model to suggest that the absence of SOCS3 in the already pro-inflammatory environment established by SOCS1 deficiency, results in hyper-responsiveness of immune cells to cytokines such as G-CSF and IL-6, and dramatically accelerates myeloid proliferation and inflammatory infiltration of target tissues.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] Myelodysplastic syndrome with refractory hemorrhage due to reduced platelet aggregation activity2017
Author(s)
Tanaka T, Kozakai T, Kitajima T, Fuse K, Kobayashi H, Ushiki T, Shibazaki Y, Moriyama M, Takizawa J, Sone H, Fuse I, Masuko M
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Journal Title
Rinsho Ketsueki
Volume: 58
Issue: 12
Pages: 2402-2405
DOI
NAID
ISSN
0485-1439, 1882-0824
Related Report
Peer Reviewed
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[Journal Article] Successful umbilical cord blood hematopoietic stem cell transplantation in a patient with adult T-cell leukemia/lymphoma initially achieving complete remission with anti-CC chemokine receptor 4 antibody combined chemotherapy2017
Author(s)
Suwabe T, Shibasaki Y, Kaihatsu A, Katagiri T, Miyakoshi S, Fuse K, Kobayashi H, Ushiki T, Moriyama M, Takizawa J, Narita M, Sone H, Masuko M.
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Journal Title
Rinsho Ketsueki
Volume: 58
Issue: 1
Pages: 32-36
DOI
NAID
ISSN
0485-1439, 1882-0824
Related Report
Peer Reviewed
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[Journal Article] CIS is a potent checkpoint in NK cell-mediated tumor immunity2016
Author(s)
Delconte RB, Kolesnik TB, Dagley LF, Rautela J, Shi W, Putz EM, Stannard K, Zhang JG, Teh C, Firth M, Ushiki T, et al.
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Journal Title
Nature Immunology
Volume: Jul;17(7)
Issue: 7
Pages: 816-824
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] CIS is a potent checkpoint in NK cell-mediated tumour immunity.2016
Author(s)
Delconte RB, Kolesnik TB, Dagley LF, Rautela J, Shi W, Putz EM,, Stannard K, Zhang JG, Teh C, Firth M, Ushiki T, et al.
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Journal Title
Nature Immunology
Volume: in press
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.2016
Author(s)
Delconte RB, Shi W, Sathe P, Ushiki T, Seillet C, Minnich M, Kolesnik TB, Rankin LC, Mielke LA, Zhang JG, Busslinger M, Smyth MJ, Hutchinson DS, Nutt SL, Nicholson SE, Alexander WS, Corcoran LM, Vivier E, Belz GT, Carotta S, Huntington ND
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Journal Title
Immunity
Volume: Volume 44, Issue 1
Issue: 1
Pages: 103-115
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Possible Involvement of Lung Cells Harboring an Abnormal Karyotype in the Pathogenesis of Pulmonary Alveolar Proteinosis Associated with Myelodysplastic Syndrome.2015
Author(s)
Moriyama M, Yano T, Furukawa T, Takada T, Ushiki T, Masuko M, Takizawa J, Sone H, Tazawa R, Saijo Y, Ishii H, Nakata K
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Journal Title
Ann Am Thorac Soc.
Volume: Vol. 12, No. 8
Pages: 1251-1253
Related Report
Peer Reviewed
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[Journal Article] The association of level of reduction of Wilms' tumor gene 1 mRNA transcript in bone marrow and outcome in acute myeloid leukemia patients.2015
Author(s)
Shibasaki Y, Seki Y, Tanaka T, Miyakoshi S, Fuse K, Kozakai T, Kobayashi H, Ushiki T, Abe T, Yano T, Moriyama M, Kuroha T, Isahai N, Takizawa J, Narita M, Koyama S, Furukawa T, Sone H, Masuko M
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Journal Title
Leuk Res.
Volume: Volume 39, Issue 6
Issue: 6
Pages: 667-671
DOI
Related Report
Peer Reviewed
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[Presentation] Patient-Based Prediction Algorithm of Relapse after Allo-HSCT for Acute Leukemia Using Machine Learning Approach2017
Author(s)
Fuse K, Uemura S, Suwabe T, Katagiri T, Tanaka T, Ushiki T, Shibasaki Y, Sato N, Yano T, Kuroha T, Hashimoto S, Furukawa T, Narita M, Sone H, Masuko M
Organizer
59th American Society of Hematology Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] Unique profile of immune reconstruction after three types of HLA-mismatched allogeneic hematopoietic cell transplantations2017
Author(s)
Uemura S, Shibasaki Y, Katagiri T, Ito H, Tanaka T, Kobayashi H, Ushiki T, Fuse K, Narita M, Sone H, Masuko M
Organizer
The 8th JSH International Symposium
Related Report
Int'l Joint Research
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[Presentation] Evaluation of Liver Iron Deposition in Transfusion-Dependent Patients By Dual-Energy CT2016
Author(s)
Kobayashi H, Yoshimura N, Katagiri T, Ushiki T, Fuse K, Shibasaki Y, Narita M, Sone H, Masuko M
Organizer
58th American Society of Hematology Annual Meeting (ASH)
Place of Presentation
San Diego Convention Center (San Diego, CA, USA)
Year and Date
2016-12-03
Related Report
Int'l Joint Research
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[Presentation] The Predictive Factors of Favorable Prognosis after Allo-HSCT for Refractory Acute Leukemia2016
Author(s)
Fuse K, Katagiri T, Shibasaki Y, Tanaka T, Ushiki T, Sato N, Yano T, Kuroha T, Hashimoto S, Furukawa T, Narita M, Sone H, Masuko M
Organizer
58th American Society of Hematology Annual Meeting (ASH)
Place of Presentation
San Diego Convention Center (San Diego, CA, USA)
Year and Date
2016-12-03
Related Report
Int'l Joint Research
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[Presentation] A pre-transplant biomarker risk index based on serum ferritin, albumin, and C-reactive protein levels that can predict the outcomes of allogeneic hematopoietic stem cell transplantation independently of the HCT-CI2016
Author(s)
Suwabe T, Shibasaki Y, Katagiri T, Miyakoshi S, Kobayashi H, Fuse K, Ushiki T, Sato N, Yano T, Moriyama M, Kuroha T, Takizawa J, Hashimoto S, Narita M, Furukawa T, Sone H, Masuko M
Organizer
21st Congress of European Hematology Association (EHA)
Place of Presentation
The Bella Center (Copenhagen, Denmark)
Year and Date
2016-06-09
Related Report
Int'l Joint Research
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[Presentation] PERIPHERAL BLOOD EOSINOPHIL COUNT AT DAY 28 AS A PROGNOSTIC INDICATOR IN ALLOGENEIC.2015
Author(s)
Kawamoto K, Shibasaki Y, Kobayashi H, Ushiki T, Sato N, Yano T, Moriyama M, Kuroha T, Takizawa J, Hashimoto S, Narita M, Furukawa T, Sone H, Masuko M
Organizer
20th Congress of European Hematology Association (EHA)
Place of Presentation
Messe Wien Exhibition & Congress Center (Vienna, Austria)
Year and Date
2015-06-11
Related Report
Int'l Joint Research
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[Presentation] The clinical relevance of MDS Transplantation Risk Index in allogeneic hematopoietic stem cell transplantation for patents.2015
Author(s)
Katagiri T, Shibasaki Y, Kobayashi H, Ushiki T, Sato N, Yano T, Moriyama M, Kuroha T, Takizawa J, Hashimoto M, Narita M, Sone H, Furukawa T, Masuko M
Organizer
The 6th JSH International Symposium 2015
Place of Presentation
Karuizawa Prince Hotel West (Karuizawa, Japan)
Year and Date
2015-05-22
Related Report
Int'l Joint Research
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