Involvement of molecular chaperone in multistage carcinogenesis of HTLV-1-infected cells
| Project/Area Number |
15K19562
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | HTLV-1 / 分子シャペロン / Heat Shock Factor 1 / プロテオチューナー法 / 分子シャペロンタンパク質 / HSF1 / ATL / 遺伝子変異 / Tax |
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| Outline of Final Research Achievements |
To understand the effect of heat shock proteins and HSF1 (Heat shock factor 1) in multistage carcinogenesis of HTLV-1-infected cells, we performed the construction of an in vivo control system of HSF1 function using by ProteoTuner technology. As a result, we succeeded in the establishment of reversible expression system of HSF1-dominant active and HSF1-dominant negative mutants for the analysis of chaperone network function during HTLV-1 infection.
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Report
(3 results)
Research Products
(11 results)
