Investigation on the effect of previous sensitization on tolerance induction by oral antigen administrarion

• Project/Area Number: 15K19567
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: The University of Tokyo
• Principal Investigator: HARADA Hiroaki 東京大学, 医学部附属病院, 助教 (40579687)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: アレルギー学 / アレルギー / 免疫寛容

Outline of Final Research Achievements

Although oral administration of ovalbumin to naive mice leads tolerance to the antigen, the same procedure to previously sensitized mice fails tolerance induction. Orally administered ovalbumin is absorbed in the intestine and carried to mesenteric lymph nodes, where T cells who recognize the antigen are prone to differentiate into regulatory T cells. However, in sensitized mice, regulatory T cell differentiation is inhibited, and it is attributed to antigen presenting cells rather than sensitized T cells.