| Project/Area Number |
15K19569
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Collagenous pathology/Allergology
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
KIMURA Naoki 東京医科歯科大学, 医学部附属病院, 助教 (00736184)
|
|---|
| Research Collaborator |
KAMIYA Mari 東京医科歯科大学, 大学院医歯学総合研究科・膠原病・リウマチ内科学, 大学院生
TAKADA Hideto 東京医科歯科大学, 大学院医歯学総合研究科・膠原病・リウマチ内科学, 学生
KIRI Yuichi 東京医科歯科大学, 大学院医歯学総合研究科・膠原病・リウマチ内科学, 大学院生
UMEZAWA Natsuka 東京医科歯科大学, 大学院医歯学総合研究科・膠原病・リウマチ内科学, 大学院生
SASAKI Hirokazu 東京医科歯科大学, 大学院医歯学総合研究科・膠原病・リウマチ内科学, 大学院生
KASAHARA Hidemi 東京医科歯科大学, 大学院医歯学総合研究科・膠原病・リウマチ内科学, 技術補佐員
YAMASAKI Katsuko 東京医科歯科大学, 大学院医歯学総合研究科・膠原病・リウマチ内科学, 技術補佐員
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 多発性筋炎 / 自己免疫性筋炎 / マウスモデル / 筋運動 / 免荷 / 運動療法 / 新規治療戦略 |
|---|
| Outline of Final Research Achievements |
C protein-induced myositis was suppressed in mice that were running on treadmill after immunization, while it was significantly severer in mice those hindlimbs were immobilized with casts. This result suggested that muscle exercise is protective against autoimmune myositis. However, it was not reproducible in spite of several trials with different protocols of running. We modified the way of cast-immobilization and compared the immobilized limb with the free limb of the same mice because the severity of myositis was too variable inter-individually to obtain significant results. Severer myositis developed in muscles of the immobilized limb. We need to show the relationship of muscle exercise and severity of myositis by experiments with another way of unloading since the cast-immobilized limb may not only be unloaded but also be ischemic.
|
