Serum hepcidin levels and osteoporosis in patients with rheumatoid arthritis

• Project/Area Number: 15K19571
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: Niigata University
• Principal Investigator: Sato Hiroe 新潟大学, 保健管理・環境安全本部, 講師 (80705963)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ヘプシジン / 関節リウマチ / 骨粗鬆症 / 骨粗しょう症 / 貧血 / 炎症

Outline of Final Research Achievements

This study investigated the serum level of hepcidin in patients with rheumatoid arthritis (RA) and sought to identify association between osteoporosis and inflammation, and differences in hepcidin levels among patients treated with certain therapeutic drugs. Serum hepcidin levels were related to the anemia of inflammation but not to bone metabolic markers and bone mineral density in patients with RA. Serum hepcidin levels were different among certain therapeutic drugs.

Research Products

• [Presentation] Serum hepcidin levels and the differences with therapeutic drugs in patients with rheumatoid arthritis (2018)
  • Author(s): Hiroe Sato, Chinatsu Takai, Eriko Hasegawa, Yumi Nomura, Daisuke Kobayashi, Hiroshi Otani, Asami Abe, Satoshi Ito, Hajime Ishikawa, Kiyoshi Nakazono, Akira Murasawa, Yoichi Kurosawa, Ayako Wakamatsu, Yukiko Nozawa, Takeshi Nakatsue, Yoko Wada, Takeshi Kuroda, Masaaki Nakano, Ichiei Narita
  • Organizer: 日本リウマチ学会学術総会
• [Presentation] 関節リウマチ患者における血清FGF23およびヘプシジン濃度と骨代謝との関連についての検討 (2018)
  • Author(s): 佐藤弘恵、高井千夏、伊藤聡、近藤直樹、中枝武司、和田庸子、風間順一郎、黒田毅、中野正明、成田一衛
  • Organizer: 日本骨粗鬆症学会