The circadian clock controls systemic anaphylactic reaction by regulating the high-affinity IgE receptor expressed on mast cells

• Project/Area Number: 15K19573
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: University of Yamanashi
• Principal Investigator: ISHIMARU Kayoko 山梨大学, 総合研究部, 助教 (10710353)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 概日時計 / マスト細胞 / アナフィラキシーショック

Outline of Final Research Achievements

Anaphylaxis is a severe systemic allergic reaction which is rapid in onset and potentially fatal, caused by excessive release of mediators including histamine from mast cells upon allergen/IgE stimulation.Increased prevalence of anaphylaxis in industrialized countries requires urgent needs for better understanding of anaphylaxis. However, the pathophysiology of the disease is not fully understood.
This study showed that expressions of high-affinity IgE receptor(FcεRI) and PU.1, a major transcription factor regulating FcεRI transcription,exhibited circadian rhythms in mast cells,depending on the mast cell-intrinsic circadian clock activity. The results suggest that the circadian clock activity controls IgE-mediated systemic anaphylactic reaction by regulating FcεRI expression on mast cells.

Research Products

• [Journal Article] Induction of colonic regulatory T cells by 5-aminosalicylic acid (5-ASA) by activating the aryl hydrocarbon receptor. (2017)
  • Author(s): Oh-oka K, Kojima Y, Uchida K, Yoda M, Ishimaru K, Nakajima S, Hemmi J, Kano H, Fujii-Kuriyama Y, Katoh R, Ito H, Nakao A
  • Journal Title: Cell Mol Gastroenterol Hepatol Volume: 印刷中 Issue: 1 Pages: 135-151
  • DOI: 10.1016/j.jcmgh.2017.03.010
  • Peer Reviewed / Open Access
• [Journal Article] <i>Clock</i>-dependent temporal regulation of IL-33/ST2-mediated mast cell response (2017)
  • Author(s): Kawauchi T, Ishimaru K, Nakamura Y, Nakano N, Hara M, Ogawa H, Okumura K, Shibata S, Nakao A
  • Journal Title: Allergology International Volume: 66 Issue: 3 Pages: 472-478
  • DOI: 10.1016/j.alit.2017.02.004
  • NAID: 130005858846
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Regulation of plasma histamine levels by the mast cell clock and its modulation by stress. (2017)
  • Author(s): Nakamura Y, Ishimaru K, Shibata S, Nakao A.
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 39934-39934
  • DOI: 10.1038/srep39934
  • Peer Reviewed / Open Access
• [Journal Article] The efficacy of sublingual immunotherapy for allergic rhinitis may vary with the time of day. (2016)
  • Author(s): Igarashi S, Suzuki K, Nakamura Y, Ishimaru K, Fukano C, Masuyama K, Ohashi-Doi K, Nakao A
  • Journal Title: Int Arch Allergy Immunol Volume: 171 Issue: 2 Pages: 111-118
  • DOI: 10.1159/000450954
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of IgE-mediated allergic reactions by pharmacologically targeting the circadian clock. (2015)
  • Author(s): Nakamura Y, Nakano N, Ishimaru K, Ando N, Katoh R, Suzuki-Inoue K, Koyanagki S, Ogawa H, Okumura K, Shibata S, Nakao A
  • Journal Title: The Journal of allergy and clinical immunology Volume: 137(4) Issue: 4 Pages: 1226-1235
  • DOI: 10.1016/j.jaci.2015.08.052
  • Peer Reviewed / Open Access
• [Journal Article] Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice. (2015)
  • Author(s): Ando N, Nakamura Y, Aoki R, Ishimaru K, Ogawa H, Okumura K, Shibata S, Shimada S, Nakao A
  • Journal Title: J Invest Dermatol Volume: 135 Issue: 12 Pages: 3001-3008
  • DOI: 10.1038/jid.2015.316
  • Peer Reviewed / Open Access
• [Remarks] 山梨大学医学部免疫学講座ホームページ
  • URL: http://www.med.yamanashi.ac.jp/clinical_basic/para0imm/kenkyuu/kenkyuu.php