| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
The aim of this study was to analyze the pathogenesis of SLE leading to optimization of the management. We selected the molecule, Milk Fat Globule Epidermal growth factor 8 (MFG-E8), with comprehensive protein analysis. We reported that MFG-E8 positive peripheral monocytes correlated with the disease activity, and were higher in patients with skin, musculoskeletal and lymphocytopenia. In addition, the subpopulations of peripheral CD8 positive T cells correlated with disease activity and were associated with some clinical organ characteristics. Our study indicated the possibility that immunological approach with serum proteins and peripheral immune cells may enable us to classify and implement personalized management.
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