Searching for a diagnostic marker and identification of important cell groups in non-IgE mediated gastrointestinal diseases
Project/Area Number |
15K19580
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Collagenous pathology/Allergology
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Research Institution | Waseda University |
Principal Investigator |
Orihara Kanami 早稲田大学, 理工学術院, 講師(任期付) (60450623)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 好酸球性消化管疾患 / 非IgE依存性食物タンパク質誘発性胃腸炎 / リンパ球刺激試験 / 食物タンパク質誘発性胃腸炎 / 消化管アレルギー / 細胞群 / サイトカイン / 細胞増殖 / 血便 / 非IgE依存性アレルギー |
Outline of Final Research Achievements |
Non-IgE-mediated eosinophilic gastrointestinal diseases are the diseases that the number of patients continues to increase all over the world, pathology of which in particular in neonates to infants is difficult to distinguish from other diseases. Thus, sometimes it causes life-thretening serious complications. Therefore, in this study, we aimed to test the practical utility of the antigen-specific lymphocyte stimulation test, which is conducted at the research level at the moment, if it can be clinically applied to the diagnosis of these diseases. As a result, it was confirmed that it can be used for diagnosis, whereas weakness remains in distinguishing these diesases from IgE-mediated (normal) food allergy. I also examined cytokines and proliferating cell sub-popiulations as applied analysis versions of antigen specific lymphocyte tests, and I was able to find differences between IgE-mediated food allergy and non-IgE-mediated eosinophilic gastrointestinal diseases.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] ene expression patterns in distinct endoscopic findings for eosinophilic gastritis in children2017
Author(s)
Sato M, Shoda T, Shimizu H, Orihara K, Futamura K, Matsuda A, Yamada Y, Yoshioka T, Shimizu T, Ohya Y, Nomura I, Matsumoto K, Arai K.
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Journal Title
JACI In Practice
Volume: in press
Related Report
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[Journal Article] Sera of patients with infantile eosinophilic gastroenteritis showed a specific increase in both thymic stromal lymphopoietin and IL-33 levels2016
Author(s)
Shoda T, Matsuda A, Arai K, Shimizu H, Morita H, Orihara K, Okada N, Narita M, Ohya Y, Saito H, Matsumoto K, Nomura I.
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Journal Title
J Allergy Clin Immunol.
Volume: in press
Issue: 1
Pages: 299-303
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Stool EDN levels in different clusters of non-IgE-mediated gastrointestinal food allergy.2017
Author(s)
Orihara K, Nomura I, Shoda T, Suzuki H, Morita H, Matsuda A, Saito H, Matsumoto K.
Organizer
The 73rd Annual Meeting of American Academy of Allergy, Asthma and Immunology
Place of Presentation
Atlanta, GA, USA
Year and Date
2017-03-03
Related Report
Int'l Joint Research
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[Presentation] Perinatal characteristics of infants with non-IgE-mediated gastrointestinal food allergy.2017
Author(s)
Nomura I, Suzuki H, Motomura K, Shoda T, Morita H, Orihara K, Ohya Y, Saito H, Matsumoto K.
Organizer
The 73rd Annual Meeting of American Academy of Allergy, Asthma and Immunology
Place of Presentation
Atlanta, GA, USA
Year and Date
2017-03-03
Related Report
Int'l Joint Research
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[Presentation] Distinct plasma chemokine levels in non-IgE-mediated gastrointestinal food allergy, compared with IgE-mediated food allergy.2016
Author(s)
Orihara K, Nomura I, Shoda T, Morita H, Suzuki H, Matsuda A, Saito H, Matsumoto K.
Organizer
The 31st Symposium of the Collegium Internationale Allergologicum
Place of Presentation
Charleston, SC, USA
Year and Date
2016-04-03
Related Report
Int'l Joint Research
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[Presentation] Plasma cytokine/chemokine profiles in non-IgE-mediated gastrointestinal food allergy.2016
Author(s)
Orihara K, Nomura I, Shoda T, Morita H, Suzuki H, Matsuda A, Saito H, Matsumoto K.
Organizer
72nd Annual Meeting of American Academy of Allergy, Asthma and Immunology
Place of Presentation
Los Angeles, CA, USA
Year and Date
2016-03-04
Related Report
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