Helicobacter pylori gastritis and1 gastric mucosal immunity in patients with HIV
| Project/Area Number |
15K19584
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Infectious disease medicine
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
Eisuke Adachi 東京大学, 医科学研究所, 助教 (80725804)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | ヘリコバクター・ピロリ / HIV感染症 / 腸管遊走性リンパ球 / マイクロビオーム / 粘膜免疫 / Helicobacter pylori / 胃粘膜免疫 / HIV/AIDS |
|---|
| Outline of Final Research Achievements |
The aim of this research is to assess the contribution of gastric mucosal immunity and Helicobcter pyloi in people living with HIV (PLWH). We conducted a prospective study of PLWH who underwent upper gastrointestinal endoscopy. Peripheral blood mononuclear cells were collected at the same point to determine the frequency of peripheral blood gut homing CD4+ T cells and CD4+ memory T cells subsets by flow cytometry and Biopsy specimens was obtained to investigate gastric micobiome. The result of this research showed the association of Gut homing CD4+ T cells with chronic active gastritis and indirect colonization resistance by host mucosal immunity may affect the gastric microbiome In PLWH with CD4>200.
|
Report
(4 results)
Research Products
(17 results)
-
-
-
[Journal Article] Rapid HIV-1 disease progression in individuals infected with a virus adapted to its host population.2016
Author(s)
Katoh J, Kawana-Tachikawa A, Shimizu A, Zhu D, Han C, Nakamura H, Koga M, Kikuchi T, Adachi E, Koibuchi T, Gao GF, Brumme ZL, Iwamoto A.
-
Journal Title
PLoS One
Volume: 11
Issue: 3
Pages: e0150397-e0150397
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
