The survival strategies of pathogenic mycobacteria in host phagocytes through ManLAM binding to glycosphingolipid
| Project/Area Number |
15K19592
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | リポアラビノマンナン（LAM） / ラクトシルセラミド（LacCer) / 結核菌 / 抗酸菌 / ヒト好中球 / 食胞成熟 / ManLAM / Hck / 非病原性抗酸菌 / PILAM / 食胞成熟阻害 / ラクトシルセラミド / リピドラフト / MAC / リポアラビノマンナン / 好中球 / 貪食 |
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| Outline of Final Research Achievements |
Mycobacterium tuberculosis inhibit the fusion of lysosome with phagosome. Here, we studied how lactosylceramide (LacCer) recognizes mycobacterial lipoarabinomannan (LAM). We showed that LacCer binds to α1,2-mannose side branches of LAM, which are common structures among mycobacterial species. Furthermore, our data suggest ManLAM inhibits the large cluster formation of LacCer on phagosomes, resulting in the abrogation of LacCer/Hck interaction. These results provide new insights into how pathogenic mycobacteria parasite in host phagocytes.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Lipoarabinomannan binding to lactosylceramide in lipid rafts is essential for the phagocytosis of mycobacteria by human neutrophils2016
Author(s)
Nakayama H, Kurihara H, Morita YS, Kinoshita T, Mauri L, Prinetti A, Sonnino S, Yokoyama N, Ogawa H, Takamori K, Iwabuchi K
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Journal Title
Sci Signal
Volume: 11
Issue: 449
Pages: 0-0
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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