Search for novel therapeutic targets focusing on activated parietal epithelial cells
| Project/Area Number |
15K19595
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 糸球体硬化 / 糸球体壁側上皮細胞 / ポドサイト / プロテオーム解析 |
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| Outline of Final Research Achievements |
Patients with end-stage renal disease who need dialysis are increasing year by year, and the number of chronic dialysis patients reaches approximately 310,000 people. If the glomeruli, that produce urine in the kidneys, collapses (glomerulosclerosis), renal function will decline. If it is possible to suppress the glomerulosclerosis, deterioration of renal function will be prevented. Therefore, it is important to understand the mechanism of glomerulosclerosis.
It was clarified that parietal epithelial cells of Bowman's capsule plays a major role of glomerulosclerosis. The purpose of this research is to investigate in what situation the parietal epithelial cells will participate the formation of glomerulosclerosis.
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Report
(4 results)
Research Products
(8 results)
