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Search for novel therapeutic targets focusing on activated parietal epithelial cells

Research Project

Project/Area Number 15K19595
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionHokkaido University

Principal Investigator

Okamoto Takayuki  北海道大学, 大学病院, 助教 (70636349)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords糸球体硬化 / 糸球体壁側上皮細胞 / ポドサイト / プロテオーム解析
Outline of Final Research Achievements

Patients with end-stage renal disease who need dialysis are increasing year by year, and the number of chronic dialysis patients reaches approximately 310,000 people. If the glomeruli, that produce urine in the kidneys, collapses (glomerulosclerosis), renal function will decline. If it is possible to suppress the glomerulosclerosis, deterioration of renal function will be prevented. Therefore, it is important to understand the mechanism of glomerulosclerosis.
It was clarified that parietal epithelial cells of Bowman's capsule plays a major role of glomerulosclerosis. The purpose of this research is to investigate in what situation the parietal epithelial cells will participate the formation of glomerulosclerosis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2017 2016

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (3 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Growth hormone therapy for a patient with idiopathic Fanconi syndrome and growth hormone deficiency2017

    • Author(s)
      Okamoto Takayuki、Sato Yasuyuki、Yamazaki Takeshi、Hayashi Asako、Takahashi Toshiyuki
    • Journal Title

      CEN Case Rep

      Volume: 6 Issue: 1 Pages: 85-87

    • DOI

      10.1007/s13730-017-0249-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vomiting in an infant with congenital nephrotic syndrome: Questions2017

    • Author(s)
      Takahashi Toshiyuki、Sato Yasuyuki、Yamazaki Takeshi、Hayashi Asako、Okamoto Takayuki
    • Journal Title

      Pediatric Nephrology

      Volume: 32 Issue: 9 Pages: 1519-1520

    • DOI

      10.1007/s00467-016-3529-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vomiting in infant with congenital nephrotic syndrome: Answers2017

    • Author(s)
      Takahashi Toshiyuki、Sato Yasuyuki、Yamazaki Takeshi、Hayashi Asako、Okamoto Takayuki
    • Journal Title

      Pediatric Nephrology

      Volume: 32 Issue: 9 Pages: 1521-1523

    • DOI

      10.1007/s00467-016-3532-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nephronophthisis with brown tumor: Old and new problems2017

    • Author(s)
      Takahashi Toshiyuki、Sato Yasuyuki、Yamazaki Takeshi、Hayashi Asako、Okamoto Takayuki
    • Journal Title

      Pediatrics International

      Volume: 59 Issue: 9 Pages: 1024-1025

    • DOI

      10.1111/ped.13341

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-Regulation of CD74 Expression in Parietal Epithelial Cells in a Mouse Model of Focal Segmental Glomerulosclerosis2016

    • Author(s)
      Yamazaki T, Sasaki S, Okamoto T, Sato Y, Hayashi A, Ariga T
    • Journal Title

      Nephron

      Volume: 134 Issue: 4 Pages: 238-252

    • DOI

      10.1159/000448221

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Activated parietal epithelial cells in CsA-induced nephropathy and its association with the podocyte injury.2017

    • Author(s)
      Hayashi A, Okamoto T, Sato Y, Yamazaki T, Takahashi T, Ariga T.
    • Organizer
      17th Congress of the International Pediatric Nephrology Association
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A case of idiopathic Fanconi syndrome with growth hormone deficiency.2017

    • Author(s)
      Okamoto T, Sato Y, Yamazaki T, Hayashi A, Takahashi T.
    • Organizer
      17th Congress of the International Pediatric Nephrology Association.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinicopathological characteristics, treatment, and outcome of tubulointerstitial nephritis and uveitis syndrome in children.2017

    • Author(s)
      Hayashi A, Okamoto T, Sato Y, Yamazaki T, Takahashi T, Ariga T.
    • Organizer
      Kidney Week 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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