| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Nephrotic syndrome is the most common chronic kidney disease in children. Most patients respond well to steroid therapy. However, many patients relapse and suffer from side effects of steroid. On the other hand, cyclosporine is effective in preventing relapse, but cyclosporine-induced nephrotoxicity is observed in some patients during long-term treatment.
I revealed some mechanisms of cyclosporine-induced nephrotoxicity. Chronic cyclosprine-induced nephrotoxicity is characterized by arteriolopathy and tubulointerstitial lesions. Tubulointerstitial lesions consist of vacuolization of the tubules, focal areas of tubular atrophy, and interstitial fibrosis. The results obtained in this study suggest that M2 alternatively activated macrophages are involved in the interstitial fibrosis and that steroid therapy promotes interstitial fibrosis by activating M2 macrophages.
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