| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Outline of Final Research Achievements |
We have hypothesized that ER stress may control the severity of asthma, both in the onset and exacerbation. To prove this hypothesis, we used two different inhaled allergens which have both association to asthma. We stimulated airway epithelial cells with house dust mite allergen, however, there were no elicitation of ER pathway both in protein and DNA levels. We next tried whether this stimulation may occur in Th2 condition, however, no excitation of ER pathway was observed under the existence of IL4 or IL13. We stimulated airway epithelial cells with Alternaria, however, no ER stress pathway was increased. These results may suppose that the alermin secretion may be independent of ER pathway.
|
