The effect of ER stress against atopic asthma in airway epithelial cells
Project/Area Number |
15K19606
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pediatrics
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Research Institution | University of Fukui |
Principal Investigator |
MURAI HIROKI 福井大学, 学術研究院医学系部門, 助教 (50464566)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | ER ストレス / 気道上皮細胞 / アレルギー / オートファジー / 小胞体ストレス応答 / 気道上皮 / 気管支喘息 |
Outline of Final Research Achievements |
We have hypothesized that ER stress may control the severity of asthma, both in the onset and exacerbation. To prove this hypothesis, we used two different inhaled allergens which have both association to asthma. We stimulated airway epithelial cells with house dust mite allergen, however, there were no elicitation of ER pathway both in protein and DNA levels. We next tried whether this stimulation may occur in Th2 condition, however, no excitation of ER pathway was observed under the existence of IL4 or IL13. We stimulated airway epithelial cells with Alternaria, however, no ER stress pathway was increased. These results may suppose that the alermin secretion may be independent of ER pathway.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] YKL-402017
Author(s)
村井 宏生
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Journal Title
Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology
Volume: 31
Issue: 5
Pages: 751-752
DOI
NAID
ISSN
0914-2649, 1882-2738
Related Report
Peer Reviewed
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