The effect of microbiota on the gut barrier maturation
| Project/Area Number |
15K19607
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
OH-OKA Kyoko 山梨大学, 総合研究部, 医学研究員 (50569019)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 小児免疫 / 腸管バリア機能 / アレルギー / 腸内細菌 / 膠原病学 |
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| Outline of Final Research Achievements |
The purpose of this study is to show whether the gut barrier maturation of infants is affected by microbiota of mother. The expression level of several tight junction proteins, which regulate intestinal barrier function, was increased depending on the week-old. Next, I analyzed whether the gut barrier maturation of infants is changed or not, after changing the microbiota of mother by administration of pro-biotics and polyphenol. It is suggested that a particular lactobacillus and resveratrol affect to the gut barrier function.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Induction of colonic regulatory T cells by 5-aminosalicylic acid (5-ASA) by activating the aryl hydrocarbon receptor.2017
Author(s)
Oh-oka K, Kojima Y, Uchida K, Yoda M, Ishimaru K, Nakajima S, Hemmi J, Kano H, Fujii-Kuriyama Y, Katoh R, Ito H, Nakao A
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Journal Title
Cell Mol Gastroenterol Hepatol
Volume: 印刷中
Issue: 1
Pages: 135-151
DOI
Related Report
Peer Reviewed / Open Access
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