Bronchial asthma induces excessive inflammation and virus replication in pandemic influenza infection.
| Project/Area Number |
15K19619
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Research Collaborator |
HASEGAWA Shunji
FUJIMOTO Yousuke
WAKABAYASHI Midori
WAKIGUCHI Hiroyuki
NAKAMURA Tamaki
HASEGAWA Hideki
AINAI Akira
IKEMOTO Kenzo
OGA Atsunori
ITOH Hiroshi
SHIRABE Komei
TODA Shoichi
ATSUTA Ryo
OHGA Shouichi
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 新型インフルエンザ / 気管支喘息 / アレルギー・ぜんそく / 感染症 / ウィルス |
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| Outline of Final Research Achievements |
Asthmatic patients present more rapid progression of respiratory distress after A(H1N1)pdm09 influenza infection than after seasonal infection. Here, we sought to clarify the pathophysiology of early deterioration in asthmatic patients after A(H1N1)pdm09 infection. In asthma/A(H1N1)pdm09 mice, inflammatory cytokines and virus titres in bronchoalveolar lavage fluid peaked at 3 days post-infection and were higher than those in non-asthmatic or seasonal influenza infection groups. Histopathological examination showed more inflammatory cell infiltration and lung tissue destruction in the asthma/A(H1N1)pdm09 group than in any other groups. Thus, bronchial asthma could be a exacerbating factor for pandemic influenza infection with excessive inflammation and virus replication within a few days after infection. Furthermore, the evaluation of pulmonary function in the treatment intervention group is in progress.
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Report
(2 results)
Research Products
(1 results)
