| Project/Area Number |
15K19621
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Kyushu University |
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Principal Investigator |
Nishiyama Kei 九州大学, 大学病院, 医師不足分野教育指導者 (60645422)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | Henoch-Shonlein紫斑病 / 自然免疫 / A20 / アレルギー性紫斑病 / Henoch-Shönlein 紫斑病 / 自然免疫リガンド / 腎血管内皮細胞 |
|---|
| Outline of Final Research Achievements |
In patients of Henoch-Shonlein purpura, A20 expression was increased compared with normal controls. Expression of A20 was compared in the presence or absence of purpura nephritis but no difference was observed. On the other hand, in cases with abdominal pain and cases with multiple symptoms, A20 expression increased, indicating that the severity of vasculitis and A20 expression are inversely correlated.Human renal glomerular vascular endothelial cells were treated with several innate immunity ligands, but no specific cytokine increase was observed.
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