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The pathogenesisiof Henoch-schoenlein purpura nephritis: Role of circulation of defective forms of IgA1.

Research Project

Project/Area Number 15K19624
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionFukushima Medical University

Principal Investigator

Ohara Shinichiro  福島県立医科大学, 医学部, 助教 (00566846)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords紫斑病性腎炎 / 小児 / 慢性腎障害
Outline of Final Research Achievements

It has been reported that the pathogenesis of Henoch-Shoenlein purpura nephritis (HSPN)may be associated with the circulation of defective forms of IgA1 or the presence of in situ immune complexes, and the onset and progression of inflammation are thought to be associated with complement components, activated macrophage and mesangial cells. It is important to control HSPN activity including steroid and immunosuppressive drugs.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (18 results)

All 2017 2016 2015

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 2 results) Presentation (9 results)

  • [Journal Article] ミゾリビン・タクロリムス併用療法が有効であったネフローゼ症候群合併重症ループス腎炎Ⅳ型の1例2017

    • Author(s)
      大原信一郎, 他
    • Journal Title

      日本小児腎不全学会雑誌

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 急性腎障害を契機に診断された後部尿道弁の4歳男児例2016

    • Author(s)
      大原信一郎, 他
    • Journal Title

      日本小児腎不全学会雑誌

      Volume: 36 Pages: 264-267

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum myeloid-related protein 8/14 level in minimal change- and glomerulonephritis-related nephrotic syndrome2016

    • Author(s)
      Ohara S, Kawasaki Y, Suyama K, et al.
    • Journal Title

      Pediatric International

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in clinical findings, pathology, and outcomes between C3 glomerulonephritis and membranoproliferazive glomerulonephritis2016

    • Author(s)
      Kawasaki Y, Ohara S, Suyama K, et al.
    • Journal Title

      Pediatric Nephrology

      Volume: 31 Pages: 1091-1099

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rituximab and low-dose cyclosporine combination therapy for steroid-resistant focal segmental glomerulosclerosis2016

    • Author(s)
      Suyama K, Kawasaki Y, Ohara S, et al.
    • Journal Title

      Pediatric International

      Volume: 58 Pages: 219-223

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum myeloid-related protein 8/14 level in minimal change- and glomerulonephritis-related nephrotic syndrome.2016

    • Author(s)
      Ohara S, Kawasaki Y, et al.
    • Journal Title

      Pediatric International

      Volume: 0 Issue: 10 Pages: 0-0

    • DOI

      10.1111/ped.12947

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differnces in clinical findings, pathology, and outcomes between C3 glomerulonephritis and membranoproliferative glomerulonephritis.2016

    • Author(s)
      Kawasaki Y, Ohara S, Suyama K, et al.
    • Journal Title

      Pediatric Nephrology

      Volume: 0 Pages: 0-0

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 濃厚な家族歴と双角子宮を契機にWT1変異による遺伝性巣状分節性糸球体硬化症と診断した1症例2015

    • Author(s)
      大原信一郎、他
    • Journal Title

      日本小児腎不全学会雑誌

      Volume: 35 Pages: 135-138

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] MRI画像により早期診断が可能であったWunderlich症候群の1女児例2015

    • Author(s)
      大原信一郎、川崎幸彦、陶山和秀、他
    • Journal Title

      日本小児腎臓病学会雑誌

      Volume: 28 Pages: 55-59

    • NAID

      130005102920

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] ミゾリビン・タクロリムス併用療法が有効であったネフローゼ症候群合併重症ループス腎炎Ⅳ型の1例2016

    • Author(s)
      大原信一郎
    • Organizer
      日本小児腎不全学会
    • Place of Presentation
      岐阜県岐阜市
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] ミゾリビン・タクロリムス併用療法が有効であったネフローゼ症候群合併重症ループス腎炎Ⅳ型の1例2016

    • Author(s)
      大原信一郎
    • Organizer
      日本小児リウマチ学会
    • Place of Presentation
      千葉県千葉市
    • Year and Date
      2016-10-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 低補体血症を伴わない膜性増殖性糸球体腎炎Ⅲ型の女児例2016

    • Author(s)
      大原信一郎
    • Organizer
      日本腎臓学会東部学術大会
    • Place of Presentation
      東京都
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 難治性ネフローゼ症候群の寛解導入における血漿交換とステロイドパルス療法併用の効果2016

    • Author(s)
      大原信一郎
    • Organizer
      日本小児科学会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 尿路感染に伴う急性腎障害を契機に診断した後部尿道弁の4歳男児例2015

    • Author(s)
      大原信一郎
    • Organizer
      日本小児腎不全学会
    • Place of Presentation
      石川県
    • Year and Date
      2015-11-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 小児難治性ネフローゼ症候群の寛解導入における血漿交換とステロイドパルス療法併用の効果2015

    • Author(s)
      大原信一郎
    • Organizer
      日本腎臓学会 東部学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 小児期に診断された常染色体優性多発性嚢胞腎(ADPKD)の臨床像2015

    • Author(s)
      大原信一郎
    • Organizer
      日本小児腎臓病学会
    • Place of Presentation
      兵庫県
    • Year and Date
      2015-06-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 過去8年間に福島県で発症した小児紫斑病性腎炎の検討2015

    • Author(s)
      大原信一郎
    • Organizer
      日本小児腎臓病学会
    • Place of Presentation
      兵庫県
    • Year and Date
      2015-06-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 小児期ADPKDの臨床像および腎容積と腎機能の関係2015

    • Author(s)
      大原信一郎
    • Organizer
      日本小児科学会
    • Place of Presentation
      大阪府
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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