| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Our PBMCs analysis showed that most innate immune cells were increased, which was consistent with previous reports. B cells were also normally differentiated and activated in acute KD. The activation status and balance between helper T cell (Th) subsets were, however, quite different from previous reports. Although the cell number of T cells in acute KD was decreased, the proportions of CD69+ T cells were higher than in FC. Furthermore, the Th subset analysis showed that the proportion of activated Th17 was significantly higher in KD than in FC. Moreover, both Th1- and Th2-skewed subjects were observed in the acute KD group. The results revealed that Th17 might be involved in the prolongation of inflammation as a result of neutrophil invasion. Different immune phenotypes were presented, which suggests that KD may not be a single pathology. These data are expected to be useful in clarifying the pathogenesis of KD.
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