he establishment of the new intestinal growth rating system in the premature infant and bowel protection strategy
| Project/Area Number |
15K19649
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | University of Fukui |
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Principal Investigator |
Okuno Takashi 福井大学, 学術研究院医学系部門(附属病院部), 助教 (80634188)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 未熟児腸管発育 / サイトカイン / 新生児乳児消化管アレルギー / 未熟児 / 腸管発育 / 消化管発育 / 新生児 / 腸保護 / 経腸栄養 |
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| Outline of Final Research Achievements |
We analyzed the clinical course such as a digestion, nutritional status of the milk of the very low birth weight infant, abdominal findings, and measured blood, urine cytokine which was thought to have intestinal growth promotion effects with clinical specimen. Using Bio-Plex cytokine assay, we measured 27 kinds of cytokine with serum and urine within one month after the life. We showed increase of serum IL-6, IL-8, IL-10, IL-12, IL-17, VEGF in a dyspeptic group. Inflammatory cytokine is associated with the gastrointestinal growth of the premature infant and we consider that the administration of drug with an anti-inflammatory response may be effective.
In the process of the study, we reported one rare case that immediate-type allergy was associated, extremely-low-birth-weight infants of the neonatal infantile gastrointestinal allergy.
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Report
(4 results)
Research Products
(1 results)
