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The ratio of urinary coproporphyrin in pediatric period

Research Project

Project/Area Number 15K19655
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Embryonic/Neonatal medicine
Research InstitutionKagawa University

Principal Investigator

Kondo Sonoko  香川大学, 医学部, 助教 (70437680)

Research Collaborator OKADA Hitoshi  香川大学, 医学部, 准教授 (30253272)
IWASE Takashi  香川大学, 医学部附属病院, 講師 (30284368)
KATO Ikuko  香川大学, 医学部, 助教 (00613720)
SUGINO Masashiro  香川大学, 医学部附属病院, 病院助教 (50793220)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
KeywordsUCP比 / 正期産児 / 早産児 / MRP2 / 尿中コプロポルフィリン
Outline of Final Research Achievements

The ratio of urinary coproporphyrinⅠto total urinary coproporphyrinⅠand Ⅲ(UCP[Ⅰ/(Ⅰ+Ⅲ)]) was analyzed by age group. The mean UCP[Ⅰ/(Ⅰ+Ⅲ)]was 0.47 at 0-6 months, 0.21 at 6 months to 1year, 0.17 at 1year, 0.13 at 2 years, 0.21 at 3 years and 0.27 at >4 years of age. In the infants<6months old, no significant correlation was noted between postnatal age and UCP[Ⅰ/(Ⅰ+Ⅲ)], whereas a significant inverse correlation was noted between corrected gestational age and UCP[Ⅰ/(Ⅰ+Ⅲ)]. Also, significant inverse correlation was observed between postnatal age and UCP[Ⅰ/(Ⅰ+Ⅲ)]in term infant group, while no significant inverse correlation was observed in preterm infant group.
Furthermore, while no significant inverse correlation was seen in preterm infants group, significant inverse correlation was seen between corrected gestational age and UCP[Ⅰ/(Ⅰ+Ⅲ)]in term infant group.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Developmental characteristics of urinary coproporphyrin I/(I + III) ratio.2016

    • Author(s)
      Kunikata J, Okada H, Itoh S, Kusaka T
    • Journal Title

      Pediatr Int

      Volume: 58 Issue: 10 Pages: 974-978

    • DOI

      10.1111/ped.12965

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 早産児と正期産児における尿中コプロポルフィリンI/(I+III)比の発達的変化2016

    • Author(s)
      近藤 園子
    • Organizer
      第61回 日本新生児成育医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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