Effect of valproic acid on murine embryonic heart and explication of molecular biology mechanism

• Project/Area Number: 15K19659
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Fukushima Medical University
• Principal Investigator: Kanai Yuji 福島県立医科大学, 医学部, 助手 (60448628)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: バルプロ酸ナトリウム / 胎児催奇形性 / 心血行動態 / 先天性心疾患 / ヒストン脱アセチル化酵素 / マイクロＲＮＡ / バルプロ酸 / マイクロRNA / 胎児心血行動態

Outline of Final Research Achievements

We evaluated the effect of valproic acid on developing murine embryonic heart function using high-resolution echocardiography in utero. By making an embryo model by VPA administration to the pregnant murine, we assessed the fetal bradycardia and reduction of carotid artery flow volume.