• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mechanisms underlying amniotic epithelium homeostasis

Research Project

Project/Area Number 15K19664
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Embryonic/Neonatal medicine
Research InstitutionTokai University

Principal Investigator

ASAI Satoshi  東海大学, 医学部, 客員講師 (70383867)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords羊膜
Outline of Final Research Achievements

We performed experiments using several approaches in search for mechanisms involved in the homeostasis of amnion, particularly amniotic epithelium. Obtained data is as follows: 1) HLA-G, believed to be involved in feto-maternal immunotolerance, shows region-dependent differential expression levels in amnion; 2) HLA-C mRNA is much higher than HLA-G mRNA, suggestive of a more important role for HLA-C; 3) mRNAs encoding ERα, ERβ, PGR are not expressed in amnion, however, PGRMC1 mRNA level is high; 4) AQP1, AQP3, SPARC and THBS1 are not regulated by addition of MK in isolated amnion epithetial cells; and 5) RNA-seq on such cells reveals a gene expression profile compatible with some of the known characteristics of amnion.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi