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The role of lamin A in cutaneous aging

Research Project

Project/Area Number 15K19673
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionGunma University

Principal Investigator

Yamada Kazuya  群馬大学, 医学部附属病院, 助教 (90420190)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsラミンA / 光老化 / 早老症 / Atypical Werner症候群 / 老化
Outline of Final Research Achievements

The objective of this study was to elucidate the sensitivity to cell damage induced by oxidative stress or UVA in fibroblasts from Atypical Werner syndrome (AWS) patient. Using immunofluorescence staining and flow cytometry analysis, the amount of early apoptotic cells and degree of intra-cellular reactive oxygen species (ROS) generation were higher in H202-or UVA-treated AWS fibroblasts than in normal fibroblasts, suggesting that repeated UV exposure may induce premature ageing of the skin in AWS patients and that protecting against sunlight is possibly important for delaying the emergence of AWS symptoms. In addition, we demonstrated that H2O2-,or UVA-induced apoptosis and necrosis in normal and AWS fibroblasts were enhanced by farnesyltransferase inhibitor (FTI) treatment, indicating that FTI might not be useful for treating our APS/AWS patient.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) (of which Invited: 1 results)

  • [Journal Article] Increased susceptibility to oxidative stress- and ultraviolet A-induced apoptosis in fibroblasts in atypical progeroid syndrome/atypical Werner syndrome with LMNA mutation2016

    • Author(s)
      Motegi S, Uchiyama A, Yamada K, Ogino S, Yokoyama Y, Perera B, Takeuchi Y, Ishikawa O
    • Journal Title

      Experimental Dermatology

      Volume: 25 Suppl 3 Issue: S3 Pages: 20-27

    • DOI

      10.1111/exd.13086

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] 皮膚の老化における核膜蛋白質ラミンAの役割2015

    • Author(s)
      茂木 精一郎
    • Organizer
      加齢皮膚医学研究会
    • Place of Presentation
      大阪
    • Year and Date
      2015-09-06
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2018-03-22  

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