Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Outline of Final Research Achievements |
cSCC is one of the major skin cancers. In this study, we tried to identify some clones specifically expressed by cSCC associated fibroblasts which could affect the proliferation and maintenance of cSCC cells. The expression of RNAs extracted from cSCC associated fibroblasts and normal dermal fibroblasts was analyzed and compared by the cDNA microarray. Sixty one clones dominantly expressed by cSCC associated fibroblasts were identified. We selected 4 clones based on past reports associated with cancer-associated fibroblasts. Thrombomodulin, one of 4 clones, was dominantly expressed in cSCC associated fibroblasts and localized in the stroma around cSCC cells by Western blotting and immunohistochemistry.
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