| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
Flow cytometric analysis showed that LMIR3 is not expressed in mouse tissue basophils, while it is highly expressed in mouse bone marrow-derived cultured basophils. LMIR3-deficient mice exhibited enhanced IgE-mediated chronic allergic inflammatory responses and IgG1/antigen-dependent passive systemic anaphylactic responses than did wild-type counterparts. This might be because inflammatory tissue basophils express LMIR3, inhibiting IgE- or IgG-dependent activation of basophils or because these responses are suppressed by LMIR3 in immune cells other than basophils. On the other hand, LMIR3-deficient basophils or dendritic cells highly induced Th2 responses as compared with wild-type counterparts, indicating that LMIR3 inhibits Th2-mediated allergic responses.
|
