Functional analysis of an inhibitory receptor LMIR3 in basophil activation and Th2-type immune responses
| Project/Area Number |
15K19677
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Juntendo University |
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Principal Investigator |
Izawa Kumi 順天堂大学, 医学(系)研究科(研究院), 助教 (80708313)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 好塩基球 / ペア型レセプター / CD300 |
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| Outline of Final Research Achievements |
Flow cytometric analysis showed that LMIR3 is not expressed in mouse tissue basophils, while it is highly expressed in mouse bone marrow-derived cultured basophils. LMIR3-deficient mice exhibited enhanced IgE-mediated chronic allergic inflammatory responses and IgG1/antigen-dependent passive systemic anaphylactic responses than did wild-type counterparts. This might be because inflammatory tissue basophils express LMIR3, inhibiting IgE- or IgG-dependent activation of basophils or because these responses are suppressed by LMIR3 in immune cells other than basophils. On the other hand, LMIR3-deficient basophils or dendritic cells highly induced Th2 responses as compared with wild-type counterparts, indicating that LMIR3 inhibits Th2-mediated allergic responses.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation.2017
Author(s)
Shiba E, Izawa K, Kaitani A, Isobe M, Maehara A, Uchida K, Maeda K, Nakano N, Ogawa H, Okumura K, Kitamura T, Shimizu T, Kitaura J
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Journal Title
J Biol Chem.
Volume: 292
Issue: 7
Pages: 2924-2932
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation.2015
Author(s)
Matsukawa T, Izawa K, Isobe M, Takahashi M, Maehara A, Yamanishi Y, Kaitani A, Okumura K, Teshima T, Kitamura T, Kitaura J
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Journal Title
Gut
Volume: 印刷中
Issue: 5
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] The role of leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 in plasmacytoid dendritic cell (pDC)2016
Author(s)
Kaitani Ayako, Izawa Kumi, Maehara Akie, Isobe Masamichi, Takamori Ayako, Uchida Shino, Nakano Nobuhiro, Maeda Keiko, Ando Tomoaki, Okumura Ko, Kitamura Toshio, Kitaura Jiro
Organizer
第45回日本免疫学会
Place of Presentation
Okinawa Convention Center・Laguna Garden Hotel
Year and Date
2016-12-05
Related Report
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