• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A functional analysis of trichohyalin-like 1 protein, a novel member of the fused-type S100 protein family.

Research Project

Project/Area Number 15K19680
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionUniversity of Toyama

Principal Investigator

Mizawa Megumi  富山大学, 附属病院, 講師 (80401834)

Research Collaborator SHIMIZU Tadamichi  
MAKINO Teruhiko  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsTCHHH1 / 表皮角化細胞 / 細胞死 / 細胞増殖能 / TCHHL1
Outline of Final Research Achievements

Trichohyalin-like 1 (TCHHL1) protein is a novel member of the fused-type S100 protein family expressed in the basal layer of the epidermis. In the present study, we examined the function of TCHHL1 in human skin. Cell proliferation was significantly suppressed in TCHHL1-supressed normal human keratinocytes (NHKs) compared with control NHKs. Furthermore, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells were significantly increased by the suppression of TCHHL1 expression. In TCHHL1-supressed NHKs, the phosphorylation of ERK, JNK and AKT was inhibited. We next examined the association of TCHHL1 with the proliferation of squamous cell carcinoma (SCC). The knockdown of TCHHL1 expression in the human SCC line HSC-1 significantly suppressed the cell proliferation and induced cell death just as that in NHKs. Accordingly, we hypothesized that TCHHL1 might be a novel therapeutic target in SCC.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (19 results)

All 2018 2017 2016 2015

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 9 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] A case of lichen planus pemphigoides with palmoplantar keratoderma.2018

    • Author(s)
      Mizawa M, Makino T, Hayashi M, Furukawa F, Shimizu T.
    • Journal Title

      Eur J Dermatol.

      Volume: 28 Pages: 100-101

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel missense mutation in exon 3 of the TRPS1 gene in a patient with a mild phenotype of tricho-rhino-phalangeal syndrome type 1.2018

    • Author(s)
      Torai R, Makino T, Mizawa M, Shimomura Y, Shimizu T
    • Journal Title

      European Journal of Dermatology

      Volume: 印刷中 Issue: 2 Pages: 271-272

    • DOI

      10.1684/ejd.2018.3233

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The 6-year follow-up of a Japanese patient with silent erythropoietic protoporphyria.2017

    • Author(s)
      Mizawa M, Makino T, Furukawa F, Torai R, Nakano H, Sawamura D, Shimizu T.
    • Journal Title

      JAAD Case Rep.

      Volume: 3 Issue: 3 Pages: 169-171

    • DOI

      10.1016/j.jdcr.2017.01.025

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of new low-dose oral anticoagulants in recalcitrant livedoid vasculopathy.2017

    • Author(s)
      Furukawa F, Mizawa M, Makino T, Shimizu T.
    • Journal Title

      BMJ Case Rep.

      Volume: - Pages: bcr-2017-219943

    • DOI

      10.1136/bcr-2017-219943

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An intermediate vascular tumour between kaposiform hemangioendothelioma and tufted angioma with regression of the skin lesion.2017

    • Author(s)
      Makino Teruhiko, Ishida Waka, Hamashima Takeru, Mizawa Megumi, Sasahara Masakiyo, Shimizu Tadamichi.
    • Journal Title

      European Journal of Dermatology

      Volume: 27 Issue: 2 Pages: 175-176

    • DOI

      10.1684/ejd.2016.2922

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of human papillomavirus type 35 in recurrent Bowen's disease lesions of the fingers.2017

    • Author(s)
      Makino T, Hara H, Mizawa M, Shimizu A, Kaira K, Shimizu T
    • Journal Title

      Eur J Dermatol.

      Volume: 27 Issue: 2 Pages: 198-200

    • DOI

      10.1684/ejd.2016.2941

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recurrent deep vein thrombosis with a protein S Tokushima mutation2017

    • Author(s)
      Torai R.、Makino T.、Mizawa M.、Hayashi M.、Furukawa F.、Niimi H.、Shimizu T.
    • Journal Title

      British Journal of Dermatology

      Volume: 178 Issue: 1

    • DOI

      10.1111/bjd.15700

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased Serum Levels of Th2-type Cytokines and Eotaxin in Fibrillar-type Dermatitis Herpetiformis.2016

    • Author(s)
      Makino T, Yoshihisa Y, Mizawa M, Tsutsui K, Nishijima C, Inaoki M, Shimizu T.
    • Journal Title

      Acta Derm Venereol

      Volume: 印刷中 Issue: 5 Pages: 642-643

    • DOI

      10.2340/00015555-2604

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The expression profile of filaggrin-2 in the normal and pathologic human oral mucosa.2016

    • Author(s)
      Makino T, Mizawa M, Inoue S, Noguchi M, Shimizu T.
    • Journal Title

      Arch Dermatol Res.

      Volume: 308 Issue: 3 Pages: 213-217

    • DOI

      10.1007/s00403-016-1627-x

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Jumihaidokuto (Shi-Wei-Ba-Du-Tang), a Kampo Formula, Decreases the Disease Activity of Palmoplantar Pustulosis.2016

    • Author(s)
      Mizawa M, Makino T, Inami C, Shimizu T.
    • Journal Title

      Dermatol Res Pract.

      Volume: 2016 Pages: 4060673-4060673

    • DOI

      10.1155/2016/4060673

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased filaggrin-2 expression in the epidermis in a case of pityriasis rotunda.2016

    • Author(s)
      Makino T, Mizawa M, Seki Y, Hayashi M, Shimizu T.
    • Journal Title

      Clin Exp Dermatol.

      Volume: 41 Issue: 2 Pages: 215-217

    • DOI

      10.1111/ced.12716

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] The expression of trichohyalin-like 1 protein in human skin xenotransplants is enhanced by ultraviolet B irradiation.2017

    • Author(s)
      Makino T, Mizawa M, Yoshihisa Y, Shimizu T.
    • Organizer
      The 47th Annual Meeting of the European Society for Dermatological Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The itching of mycosis fungoides; the investigation of eosinophil infiltration, kallikrein 5 and IL-31.2017

    • Author(s)
      Shimizu K, Andoh T, Makino T, Yoshihisa Y, Mizawa M, Shimizu T.
    • Organizer
      The 5th Annual Meeting of the International Cytokine and Interferon Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of ultraviolet B irradiation in the expression of trichohyalin-like 1 protein.2017

    • Author(s)
      Makino T, Mizawa M, Yoshihisa Y, Shimizu T.
    • Organizer
      The 42th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2017 Annual Research Report
  • [Presentation] 駆お血剤の使用方法.2017

    • Author(s)
      三澤 恵.
    • Organizer
      第68回日本東洋医学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 潜在的骨髄性プロトポルフィリン症の6年間の経過.2017

    • Author(s)
      三澤 恵,牧野輝彦,古川史奈,虎井僚太郎,中野 創,澤村大輔,清水忠道.
    • Organizer
      第41回日本小児皮膚科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 掌蹠に著明な角化性病変を伴ったLichen planus pemphigoides.2017

    • Author(s)
      三澤 恵,牧野輝彦,林 政雄,古川史奈,清水忠道.
    • Organizer
      第69回日本皮膚科学会西部支部学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 潜在的骨髄性プロトポルフィリン症の6年間の経過.2017

    • Author(s)
      三澤 恵,牧野輝彦,古川史奈,虎井僚太郎,清水忠道,中野 創,澤村大輔.
    • Organizer
      第454回日本皮膚科学会北陸地方会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Decreased filaggrin-2 expression in the epidermis in a case of pityriasis rotunda.2015

    • Author(s)
      Makino T, Mizawa M, Seki Y, Hayashi M, Shimizu T.
    • Organizer
      The 40th Annual meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      岡山市
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi