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The role of ICOS signal in dermatitis using humanized mice

Research Project

Project/Area Number 15K19682
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionUniversity of Yamanashi

Principal Investigator

OGAWA Youichi  山梨大学, 総合研究部, 助教 (20377542)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords共刺激分子 / 皮膚炎 / 接触性皮膚炎 / アトピー性皮膚炎 / 乾癬 / ヒト化マウス / ICOS / Vg4陽性gdT細胞 / 制御性T細胞
Outline of Final Research Achievements

Proper T cell activation requires at least two signals. SIgnal1: binding of MHC complex on APC and T cell receptor on T cells. Signal2: Co-stimuratory signals via APC to T cells. Lack of co-stimuratory signals results in inadequate T cell activation, leading to anergy of T cells. It is not clear how ICOS signal, one of the co-stimuratory signals, is involved in the development and exacerbation of dermatitis. We investigated the role of ICOS signal in Th1-, Th2-, Th17-type dermatitis.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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