Clinical appearance of melanoma associated with the gene mutation for therapeutic target
| Project/Area Number |
15K19684
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Shinshu University |
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Principal Investigator |
MINAGAWA Akane 信州大学, 医学部附属病院, 医員 (80467183)
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| Research Collaborator |
OKUYAMA Ryuhei
KOGA Hiroshi
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | メラノーマ / BRAF / ダーモスコピー / BRAF変異 |
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| Outline of Final Research Achievements |
When choosing a therapy for advanced melanoma, it is essential to search for the presence of BRAF gene mutation as a therapeutic target in tumor cells. In this study, we investigated the clinical morphological characteristics of melanoma associated with BRAF gene mutation. As a result, the proportion of pigmented macule was higher in the lesion with BRAF gene mutation than that without the mutation and the number of color in a lesion was variegated which included brown, red and pink. To clarify the morphological characteristics of melanoma associated with BRAF gene mutation, it is helpful not only for choosing an appropriate therapy but also for clarifying the role of BRAF gene mutation in melanoma pathology.
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Report
(3 results)
Research Products
(16 results)
