| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We investigated the effects of TNF-α and adiponectin on stratum corneum barrier function and control mechanism. TNF-α reduced total amount of ceramide and expression of ceramide synthase (CerS) 3, 4, and 6 in cultured keratinocytes. In addition, TNF-α also reduced expression of filaggrin and keratin 1. On the other hand, adiponectin increased total amount of ceramide, expression of elongase of long-chain fatty acid (ELOVL) 7 and CerS 6 and reduced expression of CerS 1 and 2. Expression of filaggrin was reduced by TNF-α, and keratin 1 was reduced by TNF-α and adiponectin. Thus, TNF-α and adiponectin may affect stratum corneum barrier function via ceramide abnormality of ceramide synthesis in keratinocytes.
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