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Analysis of PLCipsiron-PKCmicro passway in psoriasis, dermatitis ,carcinogenesis, and cataract

Research Project

Project/Area Number 15K19689
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionTohoku Medical and Pharmaceutical University (2016-2017)
Kobe University (2015)

Principal Investigator

SAKAGUCHI Masanobu  東北医科薬科大学, 医学部, 講師 (30622881)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsPLCε / プロテインキナーゼC / 皮膚炎症 / 乾癬 / ホスホリパーゼCε / 皮膚発癌 / 紫外線 / 白内障
Outline of Final Research Achievements

We have found K5 - PLCε - transgenic (TG) mouse to express specifically at skin keratinocytes had scales, acanthosis, parakeratosis, infiltration of neutrophils at epidermis. These clinical and histological changes was concordant with psoriasis vulgaris. We confirmed PLCε activated PKCμ in vitro, and then we have created a transgenic mouse (K5 - PKCμ- TG mouse) to express specifically at skin keratinocytes.
their skin didn’t have the characteristics at like psoriasis vulgaris.
From the above, the overexpression of PLCε at keratinocytes cause the change like psoriasis without PKCμ activation.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (15 results)

All 2018 2017 2016 2015

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Open Access: 7 results) Presentation (1 results)

  • [Journal Article] C.Complete regression of crateriform verruca after partial biopsy: Another type of epithelial crateriform tumor or a subtype of keratoacanthoma?2018

    • Author(s)
      Fukumoto T, Takai T, Sakaguchi M, Oka M, Nishigori C
    • Journal Title

      J Dermatology

      Volume: 印刷中 Issue: 6

    • DOI

      10.1111/1346-8138.14186

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Granulomatous reaction to permanent eyebrow makeup successfully treated with topical steroids in combination with topical tacrolimus.2018

    • Author(s)
      Iwayama T, Fukumoto T, Horita N, Sakaguchi M, Oka M, Terashi H.
    • Journal Title

      Eur J Dermatology

      Volume: 印刷中 Issue: 6 Pages: 652-654

    • DOI

      10.1684/ejd.2017.3106

    • NAID

      120006559314

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rosai-Dorfman disease and uveitis.2018

    • Author(s)
      Nakajima N, Fukumoto T, Kozaru T, Sakaguchi M, Norose K, Oka M.
    • Journal Title

      Eur J Dermatol.

      Volume: 印刷中 Issue: 5 Pages: 535-536

    • DOI

      10.1684/ejd.2017.3075

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bilateral breast keloids in an elderly woman associated with bilateral breast cancers and high concentration of serum TGF-β2017

    • Author(s)
      Sakaguchi M, Fukumoto T, Fujishima F, Fukuda K, Kozaru T, Ban M, Oka M.
    • Journal Title

      J Dermatology

      Volume: 44 Issue: 11 Pages: 1303-1308

    • DOI

      10.1111/1346-8138.13910

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concomitant confluent and reticulated papillomatosis and acanthosis nigricans in an obese girl with insulin resistance successfully treated with oral minocycline: Case report and published work review.2017

    • Author(s)
      Fukumoto T, Kozaru T, Sakaguchi M, Oka M.
    • Journal Title

      Journal of Dermatology

      Volume: 印刷中 Issue: 8 Pages: 954-958

    • DOI

      10.1111/1346-8138.13819

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rare case of vascular malformations in both skin and brain: Case report and published work review.2017

    • Author(s)
      Oka M, Sakaguchi M, Fukumoto T, Seki S, Nishigori C.
    • Journal Title

      Journal of Dermatology

      Volume: 掲載確定 Issue: 7 Pages: 813-817

    • DOI

      10.1111/1346-8138.13799

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term survival of a patient with systemic metastatic melanoma treated with nivolumab followed by vemurafenib, with the development of vitiligo.2017

    • Author(s)
      Fukumoto T, Fujiwara S, Sakaguchi M, Oka M, Kiyota N, Ejima Y, Nishigori C.
    • Journal Title

      European Journal of Dermatology

      Volume: 27(2) Issue: 2 Pages: 177-178

    • DOI

      10.1684/ejd.2016.2925

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cutaneous Rosai-Dorfman disease associated with uveitis2017

    • Author(s)
      Fukumoto T, Oka M, Masaki T, Sakaguchi M, Fukunaga A, Norose K, Sarayama Y, Imai H, Nishigori C
    • Journal Title

      Eur J Dermatol

      Volume: 27 Issue: 1 Pages: 85-86

    • DOI

      10.1684/ejd.2016.2885

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mixed connective tissue disease with bilateral erythematous palpebral edema and targetoid skin lesions.2017

    • Author(s)
      Sakaguchi, M., Takeda, T., Kodera, T., Murakami, K., Oka, M.
    • Journal Title

      Eur. J. Dermatol.

      Volume: 27 Issue: 1 Pages: 64-65

    • DOI

      10.1684/ejd.2016.2902

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Telangiectatic lichen sclerosus on the cheek successfully treated with topical tacrolimus.2016

    • Author(s)
      Jimbo H, Oka M, Fukumoto T, Yoshioka A, Miki Y, Sakaguchi M, Ogura K, Nishigori C.
    • Journal Title

      Eur J Dermatol

      Volume: in press Issue: 3 Pages: 321-322

    • DOI

      10.1684/ejd.2016.2769

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High expression of Mcl-1L via the MEK-ERK-phospho-STAT3 (Ser727) pathway protects melanocytes and melanoma from UVB-induced apoptosis.2016

    • Author(s)
      Fukumoto-T, Iwasaki-T, Okada-T, Hashimoto-T, Moon-Y, Sakaguchi-M, Fukami-Y, Nishigori-C, Oka-M.
    • Journal Title

      Genes Cells.

      Volume: 21 Issue: 2 Pages: 185-199

    • DOI

      10.1111/gtc.12330

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mucosal lichen sclerosus/lichen planus overlap syndrome with cutaneous lesions of lichen sclerosus.2016

    • Author(s)
      Yahiro C, Oka M, Fukunaga A, Fukumoto T, Sakaguchi M, Takahashi Y, Komori T, Ueda T, Nishigori C.
    • Journal Title

      Eur J Dermatol

      Volume: in press Issue: 2 Pages: 204-205

    • DOI

      10.1684/ejd.2015.2715

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acquired dermal melanocytosis confined to the palm with a review of published cases of acquired dermal melanocytosis on the hands.2015

    • Author(s)
      Nakauchi E, Oka M, Fukumoto T, Sakaguchi M, Nishigori C.
    • Journal Title

      J Dermal

      Volume: 42 Issue: 6 Pages: 1-5

    • DOI

      10.1111/1346-8138.13232

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Drug-induced photosensitivity to bicalutamide - case report and review of the literature.2015

    • Author(s)
      Lee K, Oda Y, Sakaguchi M, Yamamoto A, Nishigori C.
    • Journal Title

      Photodermatol Photoimmunol Photomed

      Volume: in press

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 皮膚と脳に多発性の海綿状血管腫を生じた1例と同様症例のまとめ2017

    • Author(s)
      坂口 正展、福本 毅、関 紳一郎、岡 昌宏、錦織 千佳子
    • Organizer
      第116回日本皮膚科学会総会
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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