| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We have found K5 - PLCε - transgenic (TG) mouse to express specifically at skin keratinocytes had scales, acanthosis, parakeratosis, infiltration of neutrophils at epidermis. These clinical and histological changes was concordant with psoriasis vulgaris. We confirmed PLCε activated PKCμ in vitro, and then we have created a transgenic mouse (K5 - PKCμ- TG mouse) to express specifically at skin keratinocytes.
their skin didn’t have the characteristics at like psoriasis vulgaris.
From the above, the overexpression of PLCε at keratinocytes cause the change like psoriasis without PKCμ activation.
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