| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
Xeroderma pigmentosum is autosomal recessive hereditary disease characterized by photosensitivity and predisposing skin cancers in sun-exposed area and it is known that early diagnosis prevent skin cancers. In conventional method, there are some problems such as time-consuming, radioisotope use, skill requiring. We showed flow cytometry based assay had strong correlation with conventional method and succeed quickly diagnosing by analyzing each cell cycle. We established new assay for evaluating DNA repair and demonstrated that is applied to not only as alternative to conventional method but also as screening for candidate of treatment drug or clarifying the pathogenesis by evaluating DNA repair activity at each cell cycle.
|
