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Dynamics and function analysis of bone marrow-derived suppresser cells in immunotherapy of malignant melanoma and its control

Research Project

Project/Area Number 15K19691
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionKobe University

Principal Investigator

Fujiwara Susumu  神戸大学, 医学研究科, 助教 (40645389)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords悪性黒色腫 / MDSC / 5-FU / anti-Gr-1 antibody / CCL2 / 抗CD4抗体 / 抗Gr-1抗体
Outline of Final Research Achievements

The purpose of this study is to investigate whether MDSC, which has been confirmed to proliferate by removal of intratumoral CD4 positive cells to mouse malignant melanoma, is suppressed and whether antitumor effect is enhanced. Anti-Gr-1 antibody and 5-FU were used to remove MDSC. As a result, even when anti-Gr-1 antibody was administered, there was no clear enhancement of antitumor effect. Next, 5-FU was used to suppress MDSC, but MDSC reduction was not observed and no obvious therapeutic effect was observed. Next, we attempted to neutralize with anti-CCL2 antibody thought to be involved in chemotaxis of MDSC, but failed to suppress tumor growth.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017 Other

All Presentation (2 results) Remarks (2 results)

  • [Presentation] Genome-wide DNA methylation analysis in melanocytes and melanomas from the same individual2017

    • Author(s)
      Susumu Fujiwara, Hiroshi Nagai, Haruki Jinbo, Tomoyo Tanaka, Masukazu Inoie, and Chikako Nishigori
    • Organizer
      the XXIII International Pigment Cell and Melanoma Research Conference
    • Place of Presentation
      Denver, Colorado
    • Year and Date
      2017-08-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 同一患者由来の悪性黒色腫と正常色素細胞のエピジェネティックス解析および新規診断マーカー探索2017

    • Author(s)
      藤原 進、永井 宏、錦織 千佳子、小濵 千裕、田中 朋代、井家 益和
    • Organizer
      第116回日本皮膚科学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2017-06-02
    • Related Report
      2016 Annual Research Report
  • [Remarks] 神戸大学皮膚科学教室

    • URL

      http://www.med.kobe-u.ac.jp/dermat/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 神戸大学皮膚科学教室 業績集

    • URL

      http://www.med.kobe-u.ac.jp/dermat/touka/jisseki/index.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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