Dynamics and function analysis of bone marrow-derived suppresser cells in immunotherapy of malignant melanoma and its control
| Project/Area Number |
15K19691
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 悪性黒色腫 / MDSC / 5-FU / anti-Gr-1 antibody / CCL2 / 抗CD4抗体 / 抗Gr-1抗体 |
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| Outline of Final Research Achievements |
The purpose of this study is to investigate whether MDSC, which has been confirmed to proliferate by removal of intratumoral CD4 positive cells to mouse malignant melanoma, is suppressed and whether antitumor effect is enhanced. Anti-Gr-1 antibody and 5-FU were used to remove MDSC. As a result, even when anti-Gr-1 antibody was administered, there was no clear enhancement of antitumor effect. Next, 5-FU was used to suppress MDSC, but MDSC reduction was not observed and no obvious therapeutic effect was observed. Next, we attempted to neutralize with anti-CCL2 antibody thought to be involved in chemotaxis of MDSC, but failed to suppress tumor growth.
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Report
(3 results)
Research Products
(4 results)
