Analysis on the influence of the HDAC inhibitor in the keloid formation
Project/Area Number |
15K19693
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Dermatology
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Research Institution | Nagasaki University |
Principal Investigator |
KUWATSUKA Yutaka 長崎大学, 医歯薬学総合研究科(医学系), 助教 (90437864)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | ケロイド / HDAC阻害剤 / エピジェネティクス |
Outline of Final Research Achievements |
We examined the gene expressions of extracellular matrix and transcription factors in keloid cells with HDAC inhibitor in vitro. Previously, we found HDAC2 was upregulated in the keloid tisuue, therefore, we choose Mocetinostat and Apicidin in addition to SAHA as HDAC inhibitors. As a result, any HDAC inhibitors could inhibit the COL1A2 mRNA expressions, especially apicidin could inhibit COL1A2 greater extent. Moreover, lower gene expressions were detected in the apicidin. These suggests apicidin improve the hypoxic stress and fibrosis in the keloid. More number of the studies and further mechanism examination would be needed.
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] Analysis of clinical symptoms and ABCC6 mutations in 76 Japanese patients with pseudoxanthoma elasticum.2017
Author(s)
Iwanaga A, Okubo Y, Yozaki M, Koike Y, Kuwatsuka Y, Tomimura S, Yamamoto Y, Tamura H, Ikeda S, Maemura K, Tsuiki E, Kitaoka T, Endo Y, Mishima H, Yoshiura KI, Ogi T, Tanizaki H, Wataya-Kaneda M, Hattori T, Utani A.
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Journal Title
Journal of Dermatology
Volume: 印刷中
Issue: 6
Pages: 644-650
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Association of elevated alpha-defensin levels with interstitial pneumonia in patients with systemic sclerosis2015
Author(s)
Sakamoto N, Kakugawa T, Hara A, Nakashima S, Yura H, Harada T, Ishimoto H, Yatera K, Kuwatsuka Y, Hara T, Ichinose K, Obase Y, Ishimatsu Y, Kohno S, Mukae H
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Journal Title
Respir Res
Volume: 16
Issue: 1
DOI
Related Report
Peer Reviewed
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