| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Elevation of stratum corneum (SC) pH influenced the expressions of nerve growth factor and semaphorin 3 in epidermis and augmented the epidermal innervation. In addition, elevation of SC pH induced scratching of flaky tail mice having filaggrin mutation with augmentation of epidermal innervation. These results suggest that elevation of SC pH is involved not only in induction of itching but also in the collaboration of environmental factors and genetic ones in the pathogenesis of atopic dermatitis.
In signal transducer and activator of transcription-6 (STAT6) mice, SC pH was downregulated with elevation of filaggrin expressions in epidermis and decrease in number of mast cells in dermis. These results suggest that epidermal innervation might be regulated by collaboration of SC pH, Th2 cytokines, mast cells, and epidermal keratinocytes.
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