• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Physiological Analysis of Skin-Resident B cells

Research Project

Project/Area Number 15K19702
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionKeio University

Principal Investigator

Adachi Takeya  慶應義塾大学, 医学部(信濃町), 訪問助教 (30573258)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords皮膚在住メモリーT細胞 / 皮膚在住メモリーB細胞 / 毛嚢 / 皮膚T細胞リンパ腫 / 菌状息肉症 / 皮膚免疫 / 免疫恒常性 / 免疫バリア / B細胞 / レジデントメモリー
Outline of Final Research Achievements

Barrier tissues including skin harbors a variety of resident leukocyte subsets to exert immune responses against external stimuli. They must be tightly regulated to maintain immunological homeostasis, which mechanisms have not been elucidated. In this study, we established a murine model recapitulating the cutaneous T cell lymphoma epidermotropism, which depended on the presence of hair follicle-derived cytokine. These results in pathological-state as well as the characterization of skin-resident memory B cells in steady-state, would contribute to the fundamental recognition of complex immune systems in skin.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report

Research Products

(6 results)

All 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (2 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] さまざまな皮膚疾患に寄与するレジデントメモリーT細胞の重要性2017

    • Author(s)
      足立剛也
    • Journal Title

      臨床皮膚科

      Volume: 71 Pages: 37-41

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Case of isolated epidermolytic acanthoma: genetic and immunohistochemical analysis2016

    • Author(s)
      Adachi T, Tanese K, Ouchi T, Igawa S, Nakano H, Ishiko A, et al
    • Journal Title

      J Dermatol

      Volume: 43 Pages: 974-975

    • DOI

      10.1111/1346-8138.13323

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current Topics 毛嚢によるレジデントメモリーT細胞の制御機構2016

    • Author(s)
      足立剛也, 永尾圭介
    • Journal Title

      実験医学

      Volume: 34 Pages: 931-934

    • Related Report
      2016 Annual Research Report
  • [Presentation] アクテムラ投与中に薬剤性過敏症症候群 (DIHS) に特徴的な症状を呈した薬疹の1例2016

    • Author(s)
      入來景吾, 大内健嗣, 澤田美穂, 向井美穂, 馬場裕子, 足立剛也, 舩越建, 天谷雅行, 高橋勇人
    • Organizer
      第46回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      京王プラザホテル (東京都新宿区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma -毛嚢による皮膚T細胞の制御機構-2016

    • Author(s)
      足立剛也
    • Organizer
      第115回日本皮膚科学会総会
    • Place of Presentation
      京都国際会館 (京都府京都市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Book] 歯科アレルギーNOW 疾患の基礎と臨床のエッセンシャル2016

    • Author(s)
      海老原全, 松村光明, 原澤秀樹, 北澤祐之, 足立剛也, 他
    • Total Pages
      187
    • Publisher
      デンタルダイヤモンド社
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi