| Project/Area Number |
15K19708
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KABASHIMA Kenji 京都大学, 医学研究科, 教授 (00362484)
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| Research Collaborator |
NAKAMA Takekuni 久留米大学, 医学部, 教授
FURUMURA Minao 元久留米大学, 医学部, 准教授
OHATA Chika 久留米大学, 医学部, 准教授
KARASHIMA Masashi 久留米大学, 医学部, 講師
ISHII Norito 久留米大学, 医学部, 准教授
OHYAMA Bungo 久留米大学, 医学部, 講師
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 円形脱毛症 / 局所免疫療法 / 免疫組織化学染色 / 皮膚樹状細胞 / iSALT / 免疫染色 |
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| Outline of Final Research Achievements |
We identified that in topical immunotherapy for alopecia areata, repetitive stimulation by hapten induces tertialy lymphoid organ-like structures "iSALT (induced skin-associated lymphoid tissue)" in human skin.
We examined the correlation between profile of infiltrating cells and the efficacy of topical immunotherapy, but there was no correlation between the degree of Treg infiltration around the hair follicle isthmus and the therapeutic effect. There was also no correlation between the ratio of CD4 to CD8 and the ratio of Treg to CD4 and the therapeutic effect. However, there were significant differences in CD20 positive B cells infiltration and HEVs (high endothelial venules) induction around hair follicle isthmus between effective case and ineffective cases, suggesting that iSALT is involved in hair follicle regeneration mechanism by topical immunotherapy. Thus, by analyzing iSALT induced by topical immunotherapy it might be possible to predict the therapeutic effect.
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