Construction of multidimensional model for the treatment of depression aiming at proper use of antidepressants

• Project/Area Number: 15K19710
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Hirosaki University
• Principal Investigator: Tomita Tetsu 弘前大学, 医学研究科, 助教 (90736365)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: うつ病 / 適正化 / 薬物療法 / パロキセチン / 薬物治療 / TCI / MADRS / 年齢

Outline of Final Research Achievements

The effects of antidepressants for depression vary widely among individuals. It is unclear about the characteristics of who show better response to antidepressants and proper dosage. In the present study, we investigated the characteristics at many viewpoints. As results, we reported many characteristics of responders to treatment and proper drug plasma concentration.
We aim to do better treatment of depression basing at present results.

Research Products

• [Journal Article] Items of the Montgomery & Aring;sberg Depression Rating Scale Associated With Response to Paroxetine Treatment in Patients With Major Depressive Disorder. (2016)
  • Author(s): Tomita T, Sato Y, Nakagami T, Tsuchimine S, Kaneda A, Kaneko S, Nakamura K, Yasui-Furukori N.
  • Journal Title: Clin Neuropharmacol. Volume: 39 Issue: 3 Pages: 135-9
  • DOI: 10.1097/wnf.0000000000000146
  • Peer Reviewed
• [Journal Article] An attempt to construct a 7-item short version of the temperament and character inventory to predict the treatment response of patients with depression; a validation study. (2016)
  • Author(s): Tomita T, Yasui-Furukori N, Kaneda A, Ishioka M, Sugawara N, Nakagami T, Nakamura K.
  • Journal Title: BMC Psychiatry. Volume: 16 Issue: 1 Pages: 290-290
  • DOI: 10.1186/s12888-016-0997-0
  • Peer Reviewed / Open Access
• [Journal Article] Effects of age on paroxetine efficacy in patients with major depressive disorder who do not exhibit an early response to treatment (2015)
  • Author(s): Tomita T, Sato Y, Nakagami T, Tsuchimine S, Kaneda A, Kaneko S, Nakamura K, Yasui-Furukori N.
  • Journal Title: Clinical Neuropharmacology Volume: 38 Issue: 1 Pages: 6-10
  • DOI: 10.1097/wnf.0000000000000058
  • Peer Reviewed / Open Access
• [Journal Article] Changes in the Temperament and Character Inventory dimensions after paroxetine treatment in patients with major depressive disorder (2015)
  • Author(s): Tomita T, Kaneda A, Nakagami T, Kaneko S, Yasui-Furukori N
  • Journal Title: Human Psychopharmacology Volume: 30 Issue: 5 Pages: 334-340
  • DOI: 10.1002/hup.2479
  • Peer Reviewed / Open Access
• [Presentation] うつ病患者の Temperament and Character Inventory（TCI）における傾向とパロキセ チン血中濃度 - 治療効果の関係について (2017)
  • Author(s): 冨田 哲
  • Organizer: 第27回日本臨床精神神経薬理学会
• [Presentation] うつ病患者における治療開始時の症状とパロキセチン血中濃度 - 治療効果の関係について (2017)
  • Author(s): 冨田 哲
  • Organizer: 第27回日本臨床精神神経薬理学会
• [Presentation] 抗うつ薬服用患者のうつ病理解の実態と治療反応について；高齢者と若年者の比較 (2016)
  • Author(s): 冨田 哲
  • Organizer: 第26回日本臨床精神神経薬理学会
  • Place of Presentation: ホルトホール大分（大分県大分市）
  • Year and Date: 2016-11-17
• [Presentation] 抗うつ薬を服用する患者への心理教育はいつ行うべきか (2016)
  • Author(s): 冨田 哲
  • Organizer: 第26回日本臨床精神神経薬理学会
  • Place of Presentation: ホルトホール大分（大分県大分市）
  • Year and Date: 2016-11-17
• [Presentation] 精神科治療の自己中断に影響する諸因子の検討 (2016)
  • Author(s): 冨田 哲
  • Organizer: 第26回日本臨床精神神経薬理学会
  • Place of Presentation: ホルトホール大分（大分県大分市）
  • Year and Date: 2016-11-17
• [Presentation] 老年期うつ病に対する抗うつ薬治療：心理教育から (2016)
  • Author(s): 冨田 哲、古郡規雄
  • Organizer: 第26回日本臨床精神神経薬理学会
  • Place of Presentation: ホルトホール大分（大分県大分市）
  • Year and Date: 2016-11-17
• [Presentation] An attempt to construct a 7-item short version of the Temperament and Character Inventory to predict the treatment response of patients with depression (2016)
  • Author(s): 冨田 哲
  • Organizer: 30th CINP World Congress
  • Place of Presentation: ソウル(大韓民国）
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] うつ病治療反応予測のためのTemperament and Character Inventory簡略版作成の試み (2015)
  • Author(s): 冨田 哲
  • Organizer: 第25回日本臨床精神神経薬理学会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-10-30
• [Presentation] 抗うつ薬服用中の患者のうつ病理解と重症度の関連について (2015)
  • Author(s): 冨田 哲
  • Organizer: 第25回日本臨床精神神経薬理学会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-10-30
• [Presentation] Receiver Operating Characteristic曲線を用いたうつ病患者における向精神薬の認知機能への影響の検討 (2015)
  • Author(s): 冨田 哲
  • Organizer: 第25回日本臨床精神神経薬理学会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-10-30