The cross-frequency coupling of neural oscillations in schizophrenia

• Project/Area Number: 15K19713
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: The University of Tokyo
• Principal Investigator: KIRIHARA Kenji 東京大学, 医学部附属病院, 助教 (80553700)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 統合失調症 / 脳波 / ミスマッチ陰性電位 / 神経オシレーション / グルタミン酸

Outline of Final Research Achievements

We investigated mismatch negativity and neural oscillations in early stages of schizophrenia. In this study, we found that mismatch negativity showed no progressive reduction, association with social functioning and cognitive functioning, and association with plasma level of glutamate in early stages of psychosis. In addition, we also found altered cross-frequency coupling of neural oscillations in early stages of psychosis. These findings suggest that mismatch negativity and the cross-frequency coupling may be useful biomarkers for early stages of schizophrenia.

Research Products

• [Journal Article] 特集 精神疾患の生物学的診断指標-現状と開発研究の展望 統合失調症バイオマーカーとしてのミスマッチ陰性電位 (2017)
  • Author(s): 藤岡 真生、越山 太輔、多田 真理子、切原 賢治、永井 達哉、荒木 剛、笠井 清登
  • Journal Title: 精神医学 Volume: 59 Issue: 9 Pages: 817-825
  • DOI: 10.11477/mf.1405205448
  • ISSN: 0488-1281, 1882-126X
  • Year and Date: 2017-09-15
• [Journal Article] Reduced Mismatch Negativity is Associated with Increased Plasma Level of Glutamate in First-episode Psychosis (2017)
  • Author(s): Nagai Tatsuya, Kirihara Kenji, Tada Mariko, Koshiyama Daisuke, Koike Shinsuke, Suga Motomu, Araki Tsuyoshi, Hashimoto Kenji, Kasai Kiyoto
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 2258-2258
  • DOI: 10.1038/s41598-017-02267-1
  • Peer Reviewed / Open Access
• [Journal Article] Association between mismatch negativity and global functioning is specific to duration deviance in early stages of psychosis (2017)
  • Author(s): Koshiyama Daisuke, Kirihara Kenji, Tada Mariko, Nagai Tatsuya, Fujioka Mao, Koike Shinsuke, Suga Motomu, Araki Tsuyoshi, Kasai Kiyoto
  • Journal Title: Schizophrenia Research Volume: - Pages: 30607-30607
  • DOI: 10.1016/j.schres.2017.09.045
  • Peer Reviewed / Open Access
• [Journal Article] Duration and frequency mismatch negativity shows no progressive reduction in early stages of psychosis (2017)
  • Author(s): Koshiyama D, Kirihara K, Tada M, Nagai T, Koike S, Suga M, Araki T, Kasai K
  • Journal Title: Schizophrenia Research Volume: 印刷中 Pages: 32-38
  • DOI: 10.1016/j.schres.2017.03.015
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Mismatch negativity in patients with early stages of psychosis and in nonhuman primates. (2017)
  • Author(s): Kenji Kirihara, Tatsuya Nagai, Yuki Suda, Mariko Tada, Daisuke Koshiyama, Shinsuke Koike, Motomu Suga, Tsuyoshi Araki, Kenji Hashimoto, Takanori Uka, Kiyoto Kasai
  • Organizer: Society of Biological Psychiatry 72nd Annual Scientific Convention
  • Int'l Joint Research