Frontal Function in Children with Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder,and the change by medication and rehabilitation

• Project/Area Number: 15K19718
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: University of Fukui
• Principal Investigator: Matsumura Yukiko 福井大学, 学術研究院医学系部門, 助教 (90640144)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ADHD / NIRS / 前頭葉 / ASD / 前頭葉機能

Outline of Final Research Achievements

We evaluated the frontal lobe function among three groups, Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), typical development (TD). We use simultaneous near-infrared spectroscopy (NIRS) with multiple neuropsychological batteries of CANTAB　and verbal fluency tasks (VFT).
ADHD and ASD groups had significantly lower brain activation in left prefrontal cortex during the spatial working memory (SWM) task of CANTAB and the VFT.
Our findings suggest that the ADHD group exhibited difficulties in spatial working memory, and that the ASD group exhibited difficulties in verbal fluency.

Research Products

• [Journal Article] Gazefinder as a clinical supplementary tool for discriminating between autism spectrum disorder and typical development in male adolescents and adults. (2016)
  • Author(s): Fujioka T, Inohara K, Okamoto Y, Masuya Y, Ishitobi M, Saito DN, Jung M, Arai S, Matsumura Y, Fujisawa TX, Narita K, Suzuki K, Tsuchiya JK, Mori N, Katayama T, Sato M, Munesue T, Okazawa H, Tomoda A, Wada Y, Kosaka H.
  • Journal Title: Molecular Autism Volume: 7 Issue: 1 Pages: 19-19
  • DOI: 10.1186/s13229-016-0083-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Altered frontal pole development affect ing self-generated working memory in children with ADHD (2015)
  • Author(s): 新井清義、岡本悠子、藤岡徹、猪原敬介、石飛信、松村由紀子、丁ミンヨン、河村佳央里、滝口慎一郎、友田明美、和田有司、平谷美智夫、松浦直己、小坂浩隆
  • Organizer: 第42回日本脳科学会
  • Place of Presentation: 宮崎
  • Year and Date: 2015-11-12
• [Presentation] ADHD児における前頭極の機能成熟：self-generated working memory時の脳活動変化 (2015)
  • Author(s): 新井清義、岡本悠子、藤岡徹、石飛信、松村由紀子、丁ミンヨン、河村佳保里、滝口慎一郎、友田明美、平谷美智夫、松浦直己、小坂浩隆
  • Organizer: 第56回日本児童青年精神医学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2015-09-24