Development of new biomarker for diagnosis and pharmacological treatment response prediction of ADHD

• Project/Area Number: 15K19719
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Shinshu University
• Principal Investigator: SASAYAMA Daimei 信州大学, 学術研究院医学系, 准教授 (90447764)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 注意欠如・多動症 / サイトカイン / コルチゾール / 唾液 / 注意欠如多動症 / バイオマーカー / メチルフェニデート

Outline of Final Research Achievements

The present study aimed to develop a new biomarker for diagnosing and understanding the pathogenesis of attention-deficit/hyperactivity disorder (ADHD). Children with and without ADHD were administered psychological tests, symptom rating scales, and IVA-CPT. Salivary cytokine and cortisol levels were measured. Our results showed that many of the salivary cytokines in children exhibit diurnal variation. Furthermore, we showed that response control and attention were significantly negatively correlated with awakening cortisol levels.

Research Products

• [Journal Article] Genome-wide quantitative trait loci mapping of the human cerebrospinal fluid proteome. (2017)
  • Author(s): 2.Sasayama D, Hattori K, Ogawa S, Yokota Y, Matsumura R, Teraishi T, Hori H, Ota M, Yoshida S, Kunugi H
  • Journal Title: Hum Mol Genet Volume: 26 Pages: 44-51
  • DOI: 10.1093/hmg/ddw366
  • Peer Reviewed
• [Journal Article] Effective Treatment of Night Terrors and Sleepwalking with Ramelteon (2016)
  • Author(s): Sasayama D, Washizuka S, Honda H
  • Journal Title: J Child Adolesc Psychopharmacol Volume: 26 Issue: 10 Pages: 948-948
  • DOI: 10.1089/cap.2016.0088
  • Peer Reviewed
• [Journal Article] 自閉スペクトラム症は増えているのか (2016)
  • Author(s): 篠山大明、本田秀夫
  • Journal Title: 臨床精神医学 Volume: 45 Pages: 29-34
• [Journal Article] 自閉スペクトラム症と児童精神科医療 (2016)
  • Author(s): 篠山大明
  • Journal Title: 信州医学雑誌 Volume: 64 Pages: 329-339
  • NAID: 130005297094
  • Peer Reviewed
• [Presentation] Association between serum IL-6 levels and cognitive abilities in children with autism spectrum disorder (2016)
  • Author(s): Daimei Sasayama, Kana Kurahashi, Kayoko Oda, Takehiko Yasaki, Yoshiyuki Yamada, Nobuhiro Sugiyama, Yuji Inaba, Yuzuru Harada, Shinsuke Washizuka, Hideo Honda
  • Organizer: CINP 2016 Seoul World Congress
  • Place of Presentation: ソウル、韓国
  • Year and Date: 2016-07-03
  • Int'l Joint Research