Development of early diagnosis method for Alzheimer's disease using brain network analysis of subjective cognitive impairment

• Project/Area Number: 15K19721
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Nagoya University
• Principal Investigator: MAKINO TAEKO 名古屋大学, 未来社会創造機構, 特任助教 (70735406)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 主観的認知障害 / アルツハイマー病 / 安静時機能的磁気共鳴画像 / 拡散テンソル画像

Outline of Final Research Achievements

The aim of this study is to clarify a characteristic of resting state functional magnetic resonance imaging and diffusion tensor imaging of older adults with subjective cognitive impairment. We examined the cognitive function and the brain imaging of the subjects. We performed the cross-sectional comparison of the brain imaging between the low memory group and the high memory group, and there are no significant differences. It needs to increase the number of subjects.

Research Products

• [Journal Article] The Associations among Insulin Resistance, Hyperglycemia, Physical Performance, Diabetes Mellitus, and Cognitive Function in Relatively Healthy Older Adults with Subtle Cognitive Dysfunction (2017)
  • Author(s): Hiroyuki Umegaki, Taeko Makino, Kazuki Uemura, Hiroyuki Shimada, Takahiro Hayashi, Xian Wu Cheng, Masafumi Kuzuya
  • Journal Title: Frontiers in Aging Neuroscience Volume: 9 Pages: 72-72
  • DOI: 10.3389/fnagi.2017.00072
  • Peer Reviewed / Open Access
• [Presentation] Apoe Epsilon 4 Status Modifies the Effects of Aerobic, Resistance, or Combined Training on Cognitive Function in Older Adults (2017)
  • Author(s): Taeko Makino, Hiroyuki Umegaki, Taeko Makino, Hiroyuki Umegaki, Takahiro Hayashi, Xian Wu Cheng, Hiroyuki Shimada, Hiroko H.Dodge, Masafumi KuzuyaXian Wu Cheng, Hiroyuki Shimada, Hiroko H.Dodge, Masafumi Kuzuya
  • Organizer: Alzheimer's Association International Conference 2017
  • Place of Presentation: London (England)
  • Year and Date: 2017-07-16
  • Int'l Joint Research
• [Presentation] 異なる運動要素が地域在住高齢者の認知機能に及ぼす影響-ApoEε4による層別の検討- (2016)
  • Author(s): 牧野多恵子, 梅垣宏行, 林尊弘, 成憲武, 吉田安子, 島田裕之, 葛谷雅文
  • Organizer: 第35回日本認知症学会学術集会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2016-12-01
• [Presentation] 地域在住高齢者におけるインスリン抵抗性と認知機能の関連 (2016)
  • Author(s): 梅垣宏行, 牧野多恵子, 上村一貴, 島田裕之, 葛谷雅文
  • Organizer: 第35回日本認知症学会学術集会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2016-12-01
• [Presentation] 基本チェックリストにおける主観的認知機能と客観的認知機能との関連 (2016)
  • Author(s): 牧野多恵子, 梅垣宏行, 林尊弘, 成憲武, 吉田安子, 島田裕之, 葛谷雅文
  • Organizer: 第6回認知症予防学会学術集会
  • Place of Presentation: 東北大学（宮城県仙台市）
  • Year and Date: 2016-09-23
• [Presentation] Effects of Aerobic, Resistance, or Combined training on Cognitive Function in Older Adults: A Randomized Controlled Trial (2016)
  • Author(s): Taeko Makino, Hiroyuki Umegaki, Xian Wu Cheng, Yasuko Yoshida, Hiroyuki Shimada, Hiroko H.Dodge, Masafumi Kuzuya
  • Organizer: Alzheimer's Association International Conference 2016
  • Place of Presentation: Tronto (Canada)
  • Year and Date: 2016-07-22
  • Int'l Joint Research
• [Presentation] 異なる運動要素が地域在住高齢者の認知機能に及ぼす影響‐豊田市運動介入ランダム化比較試験- (2016)
  • Author(s): 牧野多恵子, 上村一貴, 梅垣宏行, 成憲武, 島田裕之, 葛谷雅文
  • Organizer: 第58回日本老年医学会学術集会
  • Place of Presentation: 石川県立音楽堂・ANAクラウンプラザホテル・金沢市アートホール（石川県金沢市）
  • Year and Date: 2016-06-08
• [Presentation] 地域在住高齢者における主観的認知障害の関連要因に関する検討-豊田市運動介入研究ベースラインデータより- (2015)
  • Author(s): 牧野多恵子, 上村一貴, 梅垣宏行, 成憲武, 島田裕之, 葛谷雅文
  • Organizer: 第57回日本老年医学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-06-13