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Integrative elucidation of the neural basis of social cognitive rehabilitation effect in schizophrenia

Research Project

Project/Area Number 15K19723
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionKyoto University

Principal Investigator

Matsumoto Yukiko  京都大学, 医学研究科, 助教 (80647131)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords統合失調症 / 社会認知障害 / biological motion知覚 / 脳MRI / 社会認知 / MRI / 注意 / 眼球運動
Outline of Final Research Achievements

Seventeen schizophrenia patients and 18 healthy controls were presented with a point-light walker as biological motion (BM) stimuli. We investigated the neural basis of impaired BM processing using MRI in respect to attention deficits by eye tracker. Voxel-based morphometry was performed to evaluate the relationship between BM perception and gray matter volume. It was suggested that alteration in the temporo-parietal junction might be associated with inefficient attentional strategy, whereas dysfunctional anterior superior temporal sulcus might be correlated with deficit in higher order BM processing per se. Several cognitive levels as well as corresponding brain areas are possibly involved in the manifestation of social cognitive deficits in schizophrenia.

Academic Significance and Societal Importance of the Research Achievements

統合失調症の社会認知障害は患者の社会機能に大きく影響し、かつ治療抵抗性であり、新たな治療法開発のため、その病態解明が急務となっている。社会知覚の一種であるbiological motion知覚は他者の動きの知覚であり、視覚的注意もその認知過程に関わっているが、これまで統合失調症におけるこれらの認知機能障害の神経基盤は不明であった。本研究により、統合失調症の社会知覚障害およびそれに関与する視覚的注意には、対応する脳部位の構造異常が関わっていることが示唆された。これらの知見は社会認知リハビリテーションの開発・評価に役立つことが期待される。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Neural basis of altered earlier attention and higher order biological motion processing in schizophrenia.2017

    • Author(s)
      Matsumoto Y, Takahashi H, Miyata J, Sugihara G, Murai T, Takahashi H.
    • Journal Title

      Social Neuroscience

      Volume: Aug 25 Issue: 5 Pages: 1-8

    • DOI

      10.1080/17470919.2017.1366363

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 統合失調症の階層的社会認知処理の神経基盤 ―biological motion知覚課題を用いて―2016

    • Author(s)
      松本有紀子、高橋英之、宮田淳、杉原玄一、村井俊哉、高橋英彦
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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