An investigation of the endophenotype of risk genes in patients with schizophrenia

• Project/Area Number: 15K19725
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: Fujimoto Michiko 大阪大学, 医学系研究科, 特任助教(常勤) (50647625)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 統合失調症 / 眼球運動異常 / 中間表現型 / 遺伝子多型 / 生物学的精神医学 / 遺伝子解析

Outline of Final Research Achievements

We have previously reported that the correct rate of the discriminant analysis of 5 eye movement variables was 88% between patients with schizophrenia and healthy controls. Only 3 eye movement variables (scanpath length of free viewing task, horizontal position gain of faster lissajous task and fixation duration of far distractor task) also showed the high correct rate (82%) in the discriminant analysis between patients with schizophrenia and healthy controls. Treatment-resistant schizophrenia is thought to be one of the biomarker in the various types of schizophrenia. However eye movement variables were not different significantly when we compared patients with treatment-resistant schizophrenia to ones with not treatment-resistant schizophrenia.

Research Products

• [Journal Article] Estimated cognitive decline in patients with schizophrenia: A multicenter study. (2017)
  • Author(s): Fujino H, Sumiyoshi C, Yasuda Y, Yamamori H, Fujimoto M, Fukunaga M, Miura K, Takebayashi Y, Okada N, Isomura S, Kawano N, Toyomaki A, Kuga H, Isobe M, Oya K, Okahisa Y, Takaki M, Hashimoto N, Kato M, Onitsuka T, Ueno T, Ohnuma T, Kasai K, Ozaki N, Sumiyoshi T, Imura O, Hashimoto R
  • Journal Title: sychiatry Clin Neurosci. Volume: 印刷中 Issue: 5 Pages: 294-300
  • DOI: 10.1111/pcn.12474
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Clozapine on DNA Methylation in Peripheral Leukocytes from Patients with Treatment-Resistant Schizophrenia. (2017)
  • Author(s): Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, Watanabe S, Umehara H, Shimodera S, Nakazawa T, Kikuchi M, Nakaya A, Hashimoto H, Imoto I, Hashimoto R, Ohmori T.
  • Journal Title: Int J Mol Sci. Volume: 18 Issue: 3 Pages: 632-632
  • DOI: 10.3390/ijms18030632
  • NAID: 120006535029
  • Peer Reviewed / Open Access
• [Journal Article] Eye movement as a biomarker of schizophrenia:Using an integrated eye movement score. (2017)
  • Author(s): Morita K, Miura K, Fujimoto M, Yamamori H, Yasuda Y, Iwase M, Kasai K, Hashimoto R.
  • Journal Title: Psychiatry Clin Neurosci Volume: 71(2) Issue: 2 Pages: 104-114
  • DOI: 10.1111/pcn.12460
  • Peer Reviewed / Open Access
• [Journal Article] Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine. (2017)
  • Author(s): Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, Hashimoto R.
  • Journal Title: Schizophr Res. Volume: 181 Pages: 75-82
  • DOI: 10.1016/j.schres.2016.10.012
  • NAID: 120007037467
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Usefulness of the Wechsler Intelligence Scale short form for assessing functional outcomes in patients with schizophrenia. (2016)
  • Author(s): Sumiyoshi C, Fujino H, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Takeda M, Hashimoto R.
  • Journal Title: Psychiatry Res Volume: 245 Pages: 371-378
  • DOI: 10.1016/j.psychres.2016.08.018
  • Peer Reviewed / Open Access
• [Journal Article] Clozapine improved the syndrome of inappropriate antidiuretic hormone secretion (SIADH) in a patient with treatment-resistant schizophrenia. (2016)
  • Author(s): Fujimoto M, *Hashimoto R, Yamamori H, Yasuda Y, Ohi K, Iwatani H, Isaka Y, Takeda M.
  • Journal Title: Psychiatry Clin Neurosci Volume: 70 Issue: 10 Pages: 469-469
  • DOI: 10.1111/pcn.12435
  • Peer Reviewed / Open Access
• [Journal Article] Pharmacogenomic Study of Clozapine-Induced Agranulocytosis/Granulocytopenia in a Japanese Population (2016)
  • Author(s): Saito T, Ikeda M, Mushiroda T, Ozeki T, Kondo K, Shimasaki A, Kawase K, Hashimoto S, Yamamori H, Yasuda Y, Fujimoto M et al
  • Journal Title: Biol Psychiatry Volume: in press Issue: 8 Pages: 636-642
  • DOI: 10.1016/j.biopsych.2015.12.006
  • NAID: 120007129309
  • Peer Reviewed / Open Access
• [Journal Article] Abnormal asymmetries in subcortical brain volume in schizophrenia. (2016)
  • Author(s): Okada, N.;Nemoto, K.;Hibar, D. P.;van Erp, T. G.;Fujino, H.;Isobe, M.;Isomura, S.;Natsubori, T.;Narita, H.;Hashimoto, N.;Miyata, J.;Koike, S.; Suzuki, M.;Turner, J. A.; Ozaki, N.;Kasai, K.;Hashimoto, R.
  • Journal Title: Mol Psychiatry Volume: － Issue: 10 Pages: 1460-6
  • DOI: 10.1038/mp.2015.209
  • NAID: 120007129397
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Polygenetic Components for Schizophrenia, Bipolar Disorder and Rheumatoid Arthritis Predict Risk of Schizophrenia (2016)
  • Author(s): Ohi K, Kikuchi M, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Fujino H, Miura K, Fukunaga M, Nakaya A, Iwata N, Hashimoto R
  • Journal Title: Schizophr Res Volume: 175 Issue: 1-3 Pages: 226-229
  • DOI: 10.1016/j.schres.2016.04.009
  • Peer Reviewed
• [Journal Article] 統合失調症における補助診断ツールとしての眼球運動スコアの有用性 (2016)
  • Author(s): 藤本美智子、橋本亮太、三浦健一郎、山森英長、安田由華、大井一高、岩瀬真生、武田雅俊
  • Journal Title: 日本生物学的精神医学会誌 Volume: 27(2) Pages: 97-97
  • NAID: 130006338382
• [Journal Article] Sensory cognitive abnormalities of pain in autism spectrum disorder: a case-control study. (2015)
  • Author(s): Yasuda Y, Hashimoto R, Nakae A, Kang H, Ohi K, Yamamori H, Fujimoto M, Hagihira S, Takeda M.
  • Journal Title: Ann Gen Psychiatry. Volume: 15：8 Issue: 1 Pages: 8-8
  • DOI: 10.1186/s12991-016-0095-1
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Assessment of a multi-assay biological diagnostic test for mood disorders in a Japanesepopulation. (2015)
  • Author(s): Yamamori H, Ishima T, Yasuda Y, Fujimoto M, Kudo N, Ohi K, Hashimoto K, Takeda M, Hashimoto R.
  • Journal Title: Neurosci Lett Volume: 612 Pages: 167-171
  • DOI: 10.1016/j.neulet.2015.12.019
  • Peer Reviewed / Open Access
• [Journal Article] Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder. (2015)
  • Author(s): Hashimoto R, Nakazawa T, Tsurusaki Y, Yasuda Y, Nagayasu K, Matsumura K, Kawashima H, Yamamori H, Fujimoto M, Ohi K, Umeda-Yano S, Fukunaga M, Fujino H, Kasai A, Hayata-Takano A, Shintani N, Takeda M, Matsumoto N, Hashimoto H.
  • Journal Title: Journal of Human Genetics Volume: 61 Issue: 3 Pages: 199-206
  • DOI: 10.1038/jhg.2015.141
  • Peer Reviewed / Open Access
• [Journal Article] A Naturally Occurring Null Variant of the NMDA Type Glutamate Receptor NR3B Subunit Is a Risk Factor of Schizophrenia (2015)
  • Author(s): Matsuno H, Ohi K, Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Yano-Umeda S, Saneyoshi T, Takeda M, Hayashi Y
  • Journal Title: PLoS One Volume: 10(3) Issue: 3 Pages: e0116319-e0116319
  • DOI: 10.1371/journal.pone.0116319
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Imaging genetics and psychiatric disorders (2015)
  • Author(s): Hashimoto R, Ohi K, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Watanabe Y, Fukunaga M, Takeda M
  • Journal Title: Curr Mol Med Volume: 15(2) Pages: 168-175
  • Peer Reviewed / Open Access
• [Journal Article] Glutamate Networks Implicate Cognitive Impairments in Schizophrenia: Genome-Wide Association Studies of 52 Cognitive Phenotypes. (2014)
  • Author(s): Ohi K, Hashimoto R, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Fukunaga M, Fujino H, Watanabe Y, Iwase M, Kazui H, Iwata N, Weinberger DR, Takeda M.
  • Journal Title: Schizophr Bull. Volume: 41 Issue: 4 Pages: 909-18
  • DOI: 10.1093/schbul/sbu171
  • NAID: 40020682401
  • Peer Reviewed / Open Access
• [Presentation] 治療抵抗性統合失調症における眼球運動障害 (2016)
  • Author(s): 藤本美智子
  • Organizer: 第12回IGC第8回COCORO合同会議
  • Place of Presentation: 東京大学医学部附属病院（東京）
  • Year and Date: 2016-12-03
• [Presentation] 統合失調症における補助診断ツールとしての眼球運動スコアの信頼性 (2016)
  • Author(s): 藤本美智子、三浦健一郎、森田健太郎、山森英長、安田由華、工藤紀子、奥田詩織、岩瀬真生、宍戸恵美子、椎野智子、神保慎、宮田淳、池田学、橋本亮太
  • Organizer: 第38回日本生物学的精神医学会第59日本神経化学会大会
  • Place of Presentation: 福岡国際会議場（福岡）
  • Year and Date: 2016-09-08
• [Presentation] クロザピンによりバゾプレシン分泌過剰症（SIADH）が改善した治療抵抗性統合失調症の一例 (2016)
  • Author(s): 藤本美智子、橋本亮太、山森英長、安田由華、大井一高、岩谷博次、猪坂善隆、武田雅俊
  • Organizer: 第46回日本神経精神薬理学会年会
  • Place of Presentation: ソウル（韓国）
  • Year and Date: 2016-07-02
• [Presentation] 統合失調症における補助診断ツールとしての眼球運動スコアの有用性 (2015)
  • Author(s): 藤本美智子、橋本亮太、三浦健一郎、山森英長、安田由華、大井一高、岩瀬真生、武田雅俊
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同学会
  • Place of Presentation: タワーホール船堀（東京都）
  • Year and Date: 2015-09-24
• [Presentation] The reliability of an integrated eye movement score for biological marker of schizophrenia (2015)
  • Author(s): Fujimoto M, Hashimoto R, Miura M, Yamamori H, Yasuda Y, Ohi K, Iwase M, Takeda M
  • Organizer: The Korean Neuropsychiatric Association
  • Place of Presentation: Grand Hilton Hotel Seoul, Korea
  • Year and Date: 2015-04-03
  • Int'l Joint Research / Invited
• [Book] 精神医学症候群（第2版）-発達障害・統合失調症・双極性障害・抑うつ障害- (2017)
  • Author(s): 藤本美智子、山森英長、安田由華、池田学、橋本亮太
  • Total Pages: 627
  • Publisher: 日本臨牀
• [Remarks] 大阪大学大学院医学系研究科精神医学教室 分子精神医学研究グループ
  • URL: http://www.sp-web.sakura.ne.jp/lab/index.html
• [Remarks] 大阪大学大学院医学系研究科精神医学教室分子精神医学研究グループ
  • URL: http://www.sp-web.sakura.ne.jp/lab/index.html