| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
We explored the role of macrophage migration inhibitory factor (MIF) in the pathophysiology of schizophrenia. We found that serum MIF level is significantly higher in patients with schizophrenia than in controls. In addition, serum MIF level is significantly positively correlated with antipsychotic dose. However, there is no difference in port-mortem brain MIF level between schizophrenia and control groups. On the other hand, we found significant association of MIF gene polymorphisms with adolescent-onset female schizophrenia. Our findings suggest that MIF is involved in the pathophysiology of schizophrenia and it might be useful for a biomarker of schizophrenia. We are going to continue the investigation of the mechanism of MIF in schizophrenia using primary mouse neural cells and human iPS cells derived from patients.schizophrenia and it might be useful for a biomarker of schizophrenia.
|
