The role of macrophage migration inhibitory factor (MIF) in the neuroimmunological hypothesis of schizophrenia
Project/Area Number |
15K19727
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
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Research Institution | Kobe University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 統合失調症 / MIF / SNP / マイクロサテライト / 死後脳 / アストロサイト / 神経幹細胞 / iPS細胞 / 神経前駆細胞 / ニューロン |
Outline of Final Research Achievements |
We explored the role of macrophage migration inhibitory factor (MIF) in the pathophysiology of schizophrenia. We found that serum MIF level is significantly higher in patients with schizophrenia than in controls. In addition, serum MIF level is significantly positively correlated with antipsychotic dose. However, there is no difference in port-mortem brain MIF level between schizophrenia and control groups. On the other hand, we found significant association of MIF gene polymorphisms with adolescent-onset female schizophrenia. Our findings suggest that MIF is involved in the pathophysiology of schizophrenia and it might be useful for a biomarker of schizophrenia. We are going to continue the investigation of the mechanism of MIF in schizophrenia using primary mouse neural cells and human iPS cells derived from patients.schizophrenia and it might be useful for a biomarker of schizophrenia.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Increased serum levels and promoter polymorphisms of macrophage migration inhibitory factor in schizophrenia.2018
Author(s)
Okazaki S, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Boku S, Shimmyo N, Kinoshita M, Inoue E, Ohmori T, Someya T, Sora I.
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry.
Volume: 83
Pages: 33-41
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Loss of chromosome Y in blood, but not in brain, of suicide completers2018
Author(s)
Kimura A, Hishimoto A, Otsuka I, Okazaki S, Boku S, Horai T, Izumi T, Takahashi M, Ueno Y, Shirakawa O, Sora I
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Journal Title
PLoS One
Volume: 13
Issue: 1
Pages: e0190667-e0190667
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Aberrant telomere length and mitochondrial DNA copy number in suicide completers.2017
Author(s)
Otsuka I, Izumi T, Boku S, Kimura A, Zhang Y, Mouri K, Okazaki S, Shiroiwa K, Takahashi M, Ueno Y, Shirakawa O, Sora I, Hishimoto A
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Journal Title
Scientific Report
Volume: 7
Issue: 1
Pages: 3176-3176
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Association study of MIF promoter polymorphisms with suicide completers in the Japanese population2017
Author(s)
Naofumi Shimmyo, Akitoyo Hishimoto, Ikuo Otsuka, Satoshi Okazaki, Shuken Boku, Kentaro Mouri, Tadasu Horai, Motonori Takahashi, Yasuhiro Ueno, Osamu Shirakawa, Ichiro Sora
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Journal Title
Neuropsychiatric Disease and Treatment
Volume: 13
Pages: 899-908
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The cell cycle-related genes as biomarkers for schizophrenia.2016
Author(s)
Okazaki S, Boku S, Otsuka I, Mouri K, Aoyama S, Shiroiwa K, Sora I, Fujita A, Shirai Y, Shirakawa O, Kokai M, Hishimoto A.
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry
Volume: 70
Pages: 85-91
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Rare truncating variations and risk of schizophrenia: Whole-exome sequencing in three families with affected siblings and a three-stage follow-up study in a Japanese population.2016
Author(s)
Watanabe Y, Nunokawa A, Shibuya M, Ikeda M, Hishimoto A, Kondo K, Egawa J, Kaneko N, Muratake T, Saito T, Okazaki S, Shimasaki A, Igeta H, Inoue E, Hoya S, Sugai T, Sora I, Iwata N, Someya T
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Journal Title
Psychiatry Research
Volume: 235
Pages: 13-18
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Association analysis of the HLA-DRB1*01 and HLA-DRB1*04 with schizophrenia by tag SNP genotyping in the Japanese population.2015
Author(s)
Ratta-apha W, Boku S, Mouri K, Okazaki S, Otsuka I, Watanabe Y, Nunokawa A, Someya T, Shirakawa O, Sora I, Hishimoto A.
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Journal Title
Psychiatry Res.
Volume: 229
Issue: 1-2
Pages: 627-628
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Association analysis of the Cadherin13 gene with schizophrenia in the Japanese population.2015
Author(s)
Otsuka I, Watanabe Y, Hishimoto A, Boku S, Mouri K, Shiroiwa K, Okazaki S, Nunokawa A, Shirakawa O, Someya T, Sora I.
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Journal Title
Neuropsychiatr Dis Treat.
Volume: 11
Pages: 1381-1393
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 統合失調症における細胞周期関連遺伝子に着目した3段階mRNA発現解析2015
Author(s)
岡﨑 賢志, 菱本 明豊, 朴 秀賢, 毛利 健太朗, 白岩 恭一, 大塚 郁夫, 白井 豊, 藤田 愛子, 白川 治, 湖海 正尋, 曽良一郎
Organizer
日本生物学的精神医学会
Place of Presentation
タワーホール船堀(東京都江戸川区)
Year and Date
2015-09-24
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