| Project/Area Number |
15K19729
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | うつ病 / ストレス / 炎症 / サイトカイン / NLRP3 / IL-1β / TNFα / インフラマソーム / NLRP３ / 炎症性サイトカイン / βヒドロキシ酪酸 |
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| Outline of Final Research Achievements |
We revealed that i) stress, which plays a critical role in the onset of depression, causes neuroinflammation via the innate immune system in the brain, and that ii) the key molecule which senses stress is a cytosolic pattern recognition receptor called NLRP3. We also demonstrated that beta-hydroxybutyrate (BHB), an endogenic NLRP3 inflammasome inhibitor, showed the antidepressant effects in a rodent model of chronic unpredictable stress, and that BHB attenuated the increased levels of IL-1β in the hippocampus by stress. These findings demonstrate that BHB exerts antidepressant-like effects, possibly by inhibiting NLRP3-induced neuro-inflammation in the hippocampus, and that BHB may be a novel therapeutic candidate for the treatment of stress-related mood disorders.
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