Elucidation of neural mechanisms in antidepressant and cognitive behavioral therapy for chronic pain

• Project/Area Number: 15K19730
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Hiroshima University
• Principal Investigator: Yoshino Atsuo 広島大学, 医歯薬保健学研究科(医), 特任助教 (90633727)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 慢性疼痛 / 認知行動療法 / fMRI / 抗うつ薬治療

Outline of Final Research Achievements

We conducted cognitive behavioral therapy (CBT) or antidepressant treatment for chronic pain, and examined pain ratings, psychological ratings, and a neuroimaging method (fMRI) at pretreatment and post-treatment. Our outcomes were as follows: 1) the neural changes of the orbitofrontal cortex, inferior parietal lobule, and paracentral lobule by CBT (Yoshino et al., 2018) and 2) the different resting-state neural activities of the dorsolateral prefrontal cortex and thalamus from depressive patients and healthy controls (Yoshino et al., 2017). We clarified a pathological mechanism of chronic pain and a neural change by treatment.

Research Products

• [Journal Article] Changes in resting-state brain networks after cognitive-behavioral therapy for chronic pain (2018)
  • Author(s): Yoshino A.、Okamoto Y.、Okada G.、Takamura M.、Ichikawa N.、Shibasaki C.、Yokoyama S.、Doi M.、Jinnin R.、Yamashita H.、Horikoshi M.、Yamawaki S.
  • Journal Title: Psychological Medicine Volume: 48 Issue: 7 Pages: 1148-1156
  • DOI: 10.1017/s0033291717002598
  • Peer Reviewed
• [Journal Article] Functional Alterations of Postcentral Gyrus Modulated by Angry Facial Expressions during Intraoral Tactile Stimuli in Patients with Burning Mouth Syndrome: A Functional Magnetic Resonance Imaging Study (2017)
  • Author(s): Yoshino Atsuo、Okamoto Yasumasa、Doi Mitsuru、Okada Go、Takamura Masahiro、Ichikawa Naho、Yamawaki Shigeto
  • Journal Title: Front Psychiatry Volume: 8 Pages: 224-224
  • DOI: 10.3389/fpsyt.2017.00224
  • Peer Reviewed / Open Access
• [Journal Article] 身体症状症の認知行動療法 (特集 「身体症状症および関連症群」の臨床) (2017)
  • Author(s): 吉野敦雄, 岡本泰昌, 神人蘭, 森麻子, 高垣耕企, 堀越勝, 山脇成人
  • Journal Title: 精神科治療学 Volume: 32 Pages: 1073-1079
  • NAID: 40021324847
• [Journal Article] 慢性疼痛に対する認知行動療法の有効性 : 心理社会的考察から神経科学的考察まで (2017)
  • Author(s): 吉野敦雄，岡本泰昌，山脇成人
  • Journal Title: 日本運動器疼痛学会誌 Volume: 9 Pages: 277-285
• [Journal Article] 慢性疼痛に対する認知行動療法のエビデンスと将来への展望について (2017)
  • Author(s): 吉野敦雄, 岡本 泰昌, 神人 蘭, 森 麻子, 山脇 成人
  • Journal Title: PAIN RESEARCH Volume: 32 Pages: 260-266
  • NAID: 130007378647
• [Journal Article] Regional brain functions in the resting state indicative of potential differences between depression and chronic pain. (2017)
  • Author(s): Atsuo Yoshino, Yasumasa Okamoto, Mitsuru Doi, Naofumi Otsuru, Go Okada, Masahiro Takamura, Naho Ichikawa, Satoshi Yokoyama, Hidehisa Yamashita, and Shigeto Yamawaki.
  • Journal Title: Scientific Reports Volume: in press
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 【痛みと情動-基礎研究の最前線研究と臨床への応用-】 痛みと情動 臨床医学 慢性疼痛に対する認知行動療法と痛み情動 (2016)
  • Author(s): 吉野 敦雄, 岡本 泰昌, 神人 蘭, 土井 充, 堀越 勝, 山脇 成人
  • Journal Title: ペインクリニック Volume: 37 Pages: 765-773
• [Journal Article] 悲しみは疼痛認知を増強させる 神経生理学的研究による考察(図説) (2016)
  • Author(s): 吉野 敦雄、岡本 泰昌, 岡田 剛, 高村 真広, 山脇 成人
  • Journal Title: 広島医学 Volume: 69 Pages: 669-670
  • Peer Reviewed
• [Journal Article] Effectiveness of group cognitive behavioral therapy for somatoform pain disorder patients in Japan: A preliminary non-case-control study (2015)
  • Author(s): Atsuo Yoshino, Yasumasa Okamoto, Mitsuru Doi, Masaru Horikoshi, Kyoko Oshita, Ryuji Nakamura, Naofumi Otsuru, Shinpei Yoshimura, Keisuke Tanaka, Koki Takagaki, Ran Jinnin, Hidehisa Yamashita, Masashi Kawamoto MD and Shigeto Yamawaki
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 69 Issue: 12 Pages: 763-772
  • DOI: 10.1111/pcn.12330
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 慢性疼痛に対する認知行動療法のエビデンスと将来への展望について (2017)
  • Author(s): 吉野敦雄, 岡本泰昌, 山脇成人
  • Organizer: 第39回日本疼痛学会
  • Invited
• [Presentation] 慢性疼痛に対する認知行動療法の治療メカニズム ‐脳からこころへ‐ (2017)
  • Author(s): 吉野敦雄, 岡本泰昌, 山脇成人
  • Organizer: 第9回日本線維筋痛症学会
  • Invited
• [Presentation] Similarities and differences of spontaneous neural activity in patients with chronic pain and depression: A resting state fMRI study (2016)
  • Author(s): Atsuo Yoshino, Yasumasa Okamoto, Mitsuru Doi, Naofumi Otsuru, Go Okada and Shigeto Yamawaki
  • Organizer: 16th World Congress on Pain
  • Place of Presentation: Yokohama
  • Int'l Joint Research
• [Presentation] 情動と行動を軸とした慢性痛治療の新しい方向性 慢性疼痛に対する認知行動療法の有効性 (2016)
  • Author(s): 吉野敦雄
  • Organizer: 第9回日本運動器疼痛学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 慢性疼痛の情動に関連した脳内基盤と認知行動療法の有効性 (2015)
  • Author(s): 吉野 敦雄 岡本 泰昌 山脇 成人
  • Organizer: 第25回日本臨床精神神経薬理学会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-10-29
  • Invited
• [Presentation] 慢性疼痛に対する集団認知行動療法の治療効果について (2015)
  • Author(s): 吉野敦雄 岡本泰昌 神人蘭 森麻子 土井充 大鶴直史 山脇成人
  • Organizer: 第111回日本精神神経学会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-06-04
• [Book] Neuroimaging of Pain (2017)
  • Author(s): Yoshino Atsuo (Co-author)：Luca Saba (Editor)
  • Publisher: Springer