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Mechanisms of stress response relating to medication for depressive disorder focused on microglia

Research Project

Project/Area Number 15K19731
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionHiroshima University

Principal Investigator

Yamawaki Yosuke  広島大学, 医歯薬保健学研究院(歯), 助教 (90584061)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords炎症 / ストレス脆弱性 / ミクログリア / うつ病様行動 / PRIP / 中枢炎症 / グリア細胞 / 摂食行動 / サイトカイン / うつ病
Outline of Final Research Achievements

The objective of this study is to elucidate the roles of phospholipase C-related catalytically inactive protein in psychological stress and inflammation-induced depression-like behavior, including anorexia focusing on microglia. Prip-deficient mice showed the vulnerability against LPS-induced anorexia. We revealed that PRIP inhibits AKT-IKK signaling in hypothalamic microglia and regulates the expression of pro-inflammatory cytokines in microglia communicating with astrocyte, which contributes to maintaining the CNS environment.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 5 results,  Acknowledgement Compliant: 3 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation.2017

    • Author(s)
      Yamawaki Y, Oue K, Shirawachi S, Asano S, Harada K, Kanematsu T.
    • Journal Title

      Japanese Dental Science Review

      Volume: 53(1) Issue: 1 Pages: 18-24

    • DOI

      10.1016/j.jdsr.2016.06.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] General anesthetic actions on GABAA receptors in vivo are reduced in phospholipase C-related catalytically inactive protein knockout mice.2017

    • Author(s)
      Hayashiuchi M, Kitayama T, Morita K, Yamawaki Y, Oue K, Yoshinaka T, Asano S, Harada K, Kang Y, Hirata M, Irifune M, Okada M, Kanematsu T.
    • Journal Title

      Journal of Anesthesia

      Volume: in press Issue: 4 Pages: 531-538

    • DOI

      10.1007/s00540-017-2350-2

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phospholipase C-related catalytically inactive protein-knockout mice display increased induction of uncoupling protein 1 in adipose tissues following chronic cold exposure.2017

    • Author(s)
      Kana Oue, Yosuke Yamawaki, Satoshi Asano, Mizokami Akiko, Masato Hirata, Masahiro Irifune, Takashi Kanematsu.
    • Journal Title

      Journal of Oral Biosciences

      Volume: 印刷中 Issue: 2 Pages: 108-112

    • DOI

      10.1016/j.job.2017.04.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Immobilization stress-induced anorexia is mediated independent of MyD88.2016

    • Author(s)
      Hosoi T, Yamawaki Y, Kimura H, Ozawa K
    • Journal Title

      Neuroreport

      Volume: 27 Issue: 13 Pages: 947-7

    • DOI

      10.1097/wnr.0000000000000641

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phospholipase C-related catalytically inactive protein is a new modulator of thermogenesis promoted by β-adrenergic receptors in brown adipocytes2015

    • Author(s)
      Kana Oue, Jun Zhang, Kae Harada-Hada, Satoshi Asano, Yosuke Yamawaki, Masaki Hayashiuchi, Hisako Furusho, Takashi Takata, Masahiro Irifune, Masato Hirata, Takashi Kanematsu
    • Journal Title

      Journal of Biological Chemistry

      Volume: 291 Issue: 8 Pages: 4185-96

    • DOI

      10.1074/jbc.m115.705723

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The potential use of histone deacetylase inhibitors in the treatment of depression2015

    • Author(s)
      Fuchikami M, Morinobu S, et al.
    • Journal Title

      Progress in Neuro-Psychopharmacology & Biological Psychiatry

      Volume: 62 Pages: 00059-7

    • DOI

      10.1016/j.pnpbp.2015.03.010

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] PRIPによる脳内炎症が誘発する摂食抑制行動の調節2016

    • Author(s)
      山脇洋輔, 白輪地聡美、兼松隆
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      北海道
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Phospholipase C-related catalytically inactive protein is involved in the neuroinflammation-induced anorexia2016

    • Author(s)
      Yosuke Yamawaki, Satomi Shirawachi, Takashi Kanematsu
    • Organizer
      CINP 2016
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gene expression analysis in microglia related in antidepressant-like effect of sodium butyrate2015

    • Author(s)
      山脇洋輔, 兼松隆
    • Organizer
      第57回 歯科基礎医学会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Sodium butyrate ameliorates inflammation-induced depression-like behavior via inhibition of microglial activation2015

    • Author(s)
      Yosuke Yamawaki, Norika Yoshioka, Misako Nishida, Ayaka Murai, Takashi Kanematsu, Hiroyuki Akagi
    • Organizer
      CINP Dublin Thematic Meeting
    • Place of Presentation
      Dublin / Ireland
    • Year and Date
      2015-06-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2018-03-22  

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