Association study of the polymorphic region and methylation in the serotonin transporter gene promoter in the clinical response to drug treatment in obsessive-compulsive disorder
| Project/Area Number |
15K19734
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 強迫性障害 / Serotonin transporter / 治療反応性 / 遺伝子発現 / DNAメチル化 |
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| Outline of Final Research Achievements |
The purpose of the present study was to investigate whether gene expression, methylation, and polymorphism of serotonin transporter (5-HTT) gene is associated with obsessive-compulsive disorder (OCD) and the therapeutic responses to a selective serotonin reuptake inhibitor (SSRI) in OCD. Our results didn’t demonstrate that 5HTT gene expression, the methylation, and the polymorphism is associated with therapeutic responses to a SSRI in OCD. On the other hands, our results showed the differences of 5HTT gene expression and the methylation between the patients with OCD and healthy controls.
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Report
(3 results)
Research Products
(4 results)
